Cancer Advisor

Colorectal cancer — once considered a disease of older adults — is now the number one cause of cancer-related death in Americans under age 50 , according to new research published in the Journal of the American Medical Association (JAMA). This alarming shift marks a major public-health milestone and highlights the urgent need for better awareness, early screening, and research into causes.  A Dramatic Shift in Cancer Mortality Trends Until recently, cancers like lung, breast, and leukemia were the top killers for people under 50. But a new analysis of U.S. cancer mortality data from 1990 through 2023 shows that colorectal cancer (CRC) mortality has increased by about 1.1% per year , even as deaths from most major cancers have declined. By 2023, colorectal cancer had risen from the fifth leading cause of cancer death in younger adults to the first . ( American Hospital Association ) Key Trend Drivers Decreases in death rates for other cancers (lung, breast, leukemia, brain). ...

Authors: Yuan Yuan, Jin Sun Bitar, MaLia Walker, David Lin, January Lee, So Yung Choi, Stephen Shiao, Mourad Tighiouart, Paul H. Frankel, Peter P. Lee Affiliation: Cedars-Sinai Medical Center, Los Angeles, CA Abstract e13146  (2025 ASCO Annual Meeting) is a phase 1/2 study of ivermectin in combination with balstilimab after 1-2 prior lines of therapy for triple negative breast cancer Background: Despite recent FDA approval of immune checkpoint inhibitor (ICI) and antibody-drug conjugates (ADCs), therapeutic options for metastatic triple negative breast cancer (mTNBC) remain limited. Preclinical data showed that ivermectin induces robust T cell infiltration into breast tumors and turning “cold” tumors “hot” in mouse model of TNBC. Balstilimab is a fully humanized IgG4 anti-PD-1 agent with proven safety and efficacy in metastatic cervical cancer. The current phase I/II trial is designed to test the safety and efficacy of the combination of ivermectin and balstilimab in patients wit...

Introduction Facing a cancer diagnosis can feel like navigating an endless maze with no clear direction. The overwhelming emotions and confusion that accompany such news are shared by many. While conventional cancer treatments like chemotherapy and radiation therapy have a role to play, there’s a growing interest in alternative therapies that can complement or even replace traditional methods. Did you know that many alternative cancer treatments have been explored, offering new hope to those affected by cancer? The use of complementary and alternative medicine is becoming more prevalent as patients seek options beyond conventional medical treatments. Alternative medicine includes therapies used outside of standard medical practices, offering different approaches to treat cancer. Integrative medicine combines both conventional and alternative treatments, aiming to improve outcomes and enhance quality of life. Diverse cancer hallmarks targeted by repurposed non-oncology drugs. This figu...