Cancer Advisor

Abstract Background: Stage 4 prostate cancer has a 5-year survival rate of 37% with standard of care (SOC, e.g., androgen deprivation therapy [ADT], chemotherapy, Lu-177-PSMA-617). An optimized intervention combining repurposed drugs, supplements, diet/lifestyle, hyperthermia, and SOC components may improve outcomes. Methods : We simulated a double-blind RCT with 1,000 patients (500 per arm) with non-BRCA-mutated stage 4 prostate cancer (70% mHSPC, 30% mCRPC), comparing an integrative multimodal intervention arm (ivermectin 1.0–1.5 mg/kg/day (cycled 3 weeks on/1 off), mebendazole 500–1,500 mg/day (titrated), metformin 1,700 mg/day, vitamin C 1 g/kg IV 3 times/week, vitamin D 5,000 IU/day, curcumin 1,000 mg/day, low-glycemic Mediterranean diet, exercise, MBSR, hyperthermia [modulated electro-hyperthermia at 42°C for 60 minutes, 2–3 times weekly], plus ADT/Lu-177-PSMA-617) to a placebo arm with SOC. Primary endpoint was overall survival (OS); secondary endpoints included progression-fre...

Introduction Facing a cancer diagnosis can feel like navigating an endless maze with no clear direction. The overwhelming emotions and confusion that accompany such news are shared by many. While conventional cancer treatments like chemotherapy and radiation therapy have a role to play, there’s a growing interest in alternative therapies that can complement or even replace traditional methods. Did you know that many alternative cancer treatments have been explored, offering new hope to those affected by cancer? The use of complementary and alternative medicine is becoming more prevalent as patients seek options beyond conventional medical treatments. Alternative medicine includes therapies used outside of standard medical practices, offering different approaches to treat cancer. Integrative medicine combines both conventional and alternative treatments, aiming to improve outcomes and enhance quality of life. Diverse cancer hallmarks targeted by repurposed non-oncology drugs. This figu...