Fenbendazole and the Joe Tippens Protocol: An Updated Review (November 2025)

By Editorial Team

Introduction

The Joe Tippens Protocol revolves around the off-label use of fenbendazole (a veterinary dewormer commonly sold as Panacur C or Safe-Guard) combined with various supplements for cancer. Joe Tippens popularized this approach after claiming it contributed to his remission from metastatic small-cell lung cancer in 2017. As of November 2025, Joe Tippens remains alive and reports being cancer-free for over 8 years, continuing a maintenance version of the protocol.

Important Disclaimer: Fenbendazole is not approved by the FDA, EMA, or any regulatory body for human use or cancer treatment. There are no completed randomized controlled human clinical trials demonstrating its safety or efficacy against cancer. All human evidence is anecdotal, from case reports, or preclinical (lab/animal) studies. Self-medication carries risks, including liver injury. Always consult an oncologist or integrative physician before considering any off-label or repurposed drug.

What is the Joe Tippens Protocol?

The Joe Tippens Protocol involves fenbendazole, a drug typically used to treat parasitic infections in animals, alongside supplements and lifestyle changes. The protocol aims to disrupt cancer cell growth, though it remains experimental and lacks approval for human use by regulatory bodies like the FDA.

Joe Tippens' Story – Key Facts and Context

  • Diagnosed in 2016 with small-cell lung cancer metastasized to multiple organs; given ~3 months to live.
  • Enrolled in a pembrolizumab (Keytruda) clinical trial at MD Anderson (immunotherapy drug now known to produce durable remissions in some patients).
  • Started fenbendazole (222 mg/day) + supplements after hearing an anecdotal report from a veterinarian about its use in animals.
  • Achieved complete remission by early 2017.
  • Critical confounding factor: He was the only patient in his Keytruda trial cohort to achieve remission, but Keytruda alone can cure a subset of patients with high tumor mutational burden or microsatellite instability.
  • As of 2025, Joe reports scaling back fenbendazole to 3 days/week for prevention and remains in remission.
Lifestyle Recommendations:

  • Diet: Eliminate refined sugars and processed foods; focus on whole foods like vegetables, lean proteins, and healthy fats.
  • Exercise: Engage in regular physical activity, tailored to your health status.
  • Stress Management: Practice mindfulness, meditation, or other stress-reduction techniques.
Important Note: Dosing should be guided by a healthcare provider, as fenbendazole and ivermectin are not approved for human cancer treatment, and high doses may pose risks.

Sources:

Current Versions of the Joe Tippens Protocol (2025)

Original / Classic Joe Tippens Protocol
  • Fenbendazole: 222 mg daily (1 gram packet of Panacur C or Safe-Guard). Take with food/fats for better absorption. Originally 3 days on/4 off, later switched to daily.
  • Core supplements (Vitamin E was removed in later updates due to interactions):
    • Full-spectrum CBD oil: 25–50 mg/day
    • Curcumin (bioavailable form): 600 mg/day
    • Berberine: 500–600 mg/day (to restrict glucose uptake)
Updated "Onco-Adjunct" Pathways (promoted by Joe Tippens under UltraBotanica branding)
  • Pathway 1 → High-bioavailability CBD + frankincense
  • Pathway 2 → UltraCurcumin + UltraQuercetin + frankincense
  • Pathway 3 → UltraBerberine (taken with meals to mimic metformin effects)
  • Pathway 4 (newer) → EGCG + resveratrol + fisetin + beta-glucans
2024–2025 "Turbocharged" Protocols (e.g., Dr. William Makis and community variations)Most modern versions combine fenbendazole with ivermectin and/or mebendazole for purported synergy:
  • Fenbendazole: 222–444 mg daily (up to 1,000 mg in aggressive cases), usually 6–7 days/week with 1 day off
  • Ivermectin: 0.5–2 mg/kg body weight (commonly 24–60 mg flat dose), daily or 5–7 days/week, taken with a high-fat meal
  • Mebendazole (prescription human alternative): 100–400 mg daily (some reports up to 1,500 mg); often alternated with or used instead of fenbendazole
  • Bioavailable curcumin: 600–800 mg daily
  • Berberine: 500–1,000 mg daily
  • Vitamin D3 + K2: 2,500–5,000 IU daily
  • Diet: Strict no-sugar, very low-carb or full ketogenic (cancer “starvation” strategy)
Many users now cycle benzimidazoles (fenbendazole or mebendazole) together with ivermectin.
Sources:

The Science Behind Fenbendazole

Key Scientific Evidence

Other Key Studies
Read More: Fenbendazole cancer success stories (More than 350 case reposts)
Joe Tippens’ Story
In 2016, Joe Tippens was diagnosed with stage 4 small cell lung cancer and given a prognosis of three months. While participating in a clinical trial for Keytruda (pembrolizumab), an FDA-approved immunotherapy, Tippens began the fenbendazole protocol after learning about its potential from a friend. He credits the combination of fenbendazole, supplements, and lifestyle changes with his remission, as his tumors reportedly disappeared within months.

Important Context: Tippens’ participation in the Keytruda trial may have contributed to his outcome, as immunotherapy is effective in some lung cancer cases. The relative contributions of Keytruda and fenbendazole to his recovery are unclear, highlighting the need for controlled studies.
Case Reports and Anecdotal Evidence
Large compilations of anecdotal case reports and testimonials (250–350+ across cancer types, 2021–2025): Examples include https://www.onedaymd.com/2024/02/fenbendazole-cancer-success-stories.html (regularly updated)

Limitations: These cases lack peer-reviewed publication and detailed clinical data (e.g., imaging, concurrent therapies). Some cancers may respond to other treatments or be misdiagnosed as parasitic infections, which fenbendazole could treat. Balanced reporting includes noting that not all patients experience benefits, and outcomes vary widely.
Risks and Considerations
The Joe Tippens Protocol is experimental, and potential risks include:

  • Side Effects: Fenbendazole may cause liver toxicity or gastrointestinal issues at high doses, though human data is limited [4].
  • Drug Interactions: Curcumin’s antioxidant properties may reduce the efficacy of chemotherapy or radiation, which rely on oxidative stress to kill cancer cells [6].
  • Lack of Regulation: Fenbendazole for human use is not FDA-approved, and sourcing from veterinary suppliers carries risks of contamination or incorrect dosing.
Always consult a healthcare provider before starting the protocol, especially if undergoing conventional cancer treatments.
Controversies and Misinformation
The protocol’s popularity surged after Tippens’ story went viral, leading to widespread interest and some misinformation:

  • 2020 South Korea Fenbendazole Scandal: Misleading claims about fenbendazole’s efficacy led to overuse, with some patients abandoning conventional treatments. This underscores the need for verified information.
  • Misdiagnosis Hypothesis: Some speculate that cancers responsive to fenbendazole may be parasitic infections misdiagnosed as cancer. However, Tippens’ diagnosis was confirmed via biopsy, making this unlikely in his case.
  • Anecdotal vs. Scientific Evidence: The protocol’s reliance on personal stories rather than large-scale trials has fueled debate about its validity.
Readers should approach claims critically and seek information from reputable sources like the National Cancer Institute (NCI) or peer-reviewed journals.
Frequently Asked Questions (FAQs)
  1. Is fenbendazole safe for human use?
    • Fenbendazole is not approved for human cancer treatment. Limited studies suggest it’s well-tolerated at specific doses, but long-term safety is unknown. Consult a doctor before use.
  2. Can I combine the protocol with chemotherapy?
    • Some components (e.g., curcumin) may interfere with chemotherapy. Discuss with your oncologist to avoid interactions.
  3. Where can I source fenbendazole?
    • Veterinary products like Panacur C are commonly used, but sourcing for human use is unregulated. Ensure purity and consult a healthcare provider.
  4. Are there clinical trials for fenbendazole?
    • As of 2025, human trials are limited. Check ClinicalTrials.gov for updates on ongoing studies.
Next Steps
If you’re considering the Joe Tippens Protocol:

  • Consult a Healthcare Provider: Discuss the protocol’s risks and benefits with an oncologist or integrative medicine specialist.
  • Stay Informed: Visit reputable resources like the NCI (cancer.gov) or FLCCC (covid19criticalcare.com) for updates on fenbendazole research.
  • Join Support Groups: Engage with verified communities, such as those on X or cancer forums, to learn from others’ experiences while verifying information.
Recommendations (2025 Perspective)
  1. Never abandon conventional oncology care — fenbendazole is at best an adjunct.
  2. If you choose to explore it despite the lack of evidence:
    • Use only pharmaceutical-grade product (Panacur C or lab-tested pure powder)
    • Start at the standard 222 mg/day and increase only if tolerated
    • Always take with dietary fat for absorption
    • Consider prescription mebendazole instead (better human safety data)
  3. Most promising adjuncts based on mechanistic and anecdotal synergy: ivermectin, berberine, bioavailable curcumin, ketogenic diet.
  4. Await proper trials — several mebendazole studies are actively recruiting; fenbendazole pilot studies are being planned but none are active yet.

Conclusion

The Joe Tippens Protocol offers hope to some cancer patients, but its evidence is primarily anecdotal and preclinical. While Joe Tippens’ story and case reports are compelling, the protocol’s effectiveness remains unproven without large-scale clinical trials. Potential risks, such as drug interactions and lack of regulation, underscore the need for medical supervision. By combining curiosity with caution, readers can explore this experimental approach responsibly while prioritizing evidence-based care.

As of November 2025, fenbendazole cannot be recommended as a proven or standard cancer treatment by most conventional oncologists. The expanding body of case reports and strong mechanistic rationale justify urgent clinical trials, but until those results are available, any use should be cautious, closely monitored, and never in lieu of evidence-based therapy. Stay informed, stay skeptical, and always work hand-in-hand with your medical team.


Disclaimer: The information in this article is for educational purposes only and does not constitute medical advice. The Joe Tippens Protocol is an experimental approach not approved by the FDA for cancer treatment. Always consult a qualified healthcare professional before starting any new treatment.






Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.
  • Prescribed by licensed medical professionals
  • Compounded and dispensed by a licensed US-based pharmacy
  • Approved for human use
Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.

Comments

  1. Kathryn KellyOctober 12, 2025 at 9:49 AM

    IVM and fenbendazole are winners in cancer treatment, as my husband can testify. Unfortunately there is someone on X impersonating Joe Tippens, whose real Facebook account says is the only social media account he has. They are using Tippens' name to con people out of hundreds of dollars for IVM and fenbendazole, scamming the sick and the elderly. I have tried to report him to X but can't get through their AI wall. So be careful and DO NOT order from the grifter on X!

    ReplyDelete

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