Cancer Advisor

Keytruda - $29.5 billion Darzalex - $9 billion Opdivo - $7 billion Imbruvica - $5billion Tagrisso - $5 billion Revlimid - $4 billion Verzenio - $4 billion Imfinzi - $4 billion Ibrance - $3 billion Tecentriq - $3 billion In the rapidly evolving field of oncology, several cancer drugs have become best-sellers due to their proven effectiveness against various cancer types. Below, we examine some of the top-selling cancer drugs, highlighting their FDA-approved indications, mechanisms of action, and sales figures. 1. Keytruda (Pembrolizumab) - $29.5 billion Keytruda is the world's bestselling cancer drug by a large margin. (Merck & Co.) Company: Merck & Co. 2024 sales: $29.5 billion Indications Approved by FDA: Melanoma,  ( KEYNOTE-006 and KEYNOTE-054 trials) Non-small cell lung cancer,  ( KEYNOTE-010, KEYNOTE-407, KEYNOTE-189, KEYNOTE 671 trials) head and neck cancer,  ( KEYNOTE-012 and KEYNOTE-048) kidney cancer (renal cell carcinoma),  ( KEYNOTE-426) classical ...

Quick Answer: Metformin's repurposing for cancer gained momentum after studies showed diabetic patients taking it had significantly lower cancer rates and mortality. It is now studied as a gerotherapeutic agent targeting aging processes linked to cancer, with innovative research exploring higher doses, drug combinations (like immunotherapy), nanoformulations for targeted delivery, and personalized treatment based on biomarkers. If ongoing large trials confirm its benefits, metformin could make cancer care more accessible worldwide due to its affordability. However, robust randomized controlled trials are still needed to establish clear guidelines for its use in oncology. Historical Background Metformin originates from Galega officinalis, also known as Goat's Rue, a traditional herbal remedy used in Europe for diabetes-like symptoms for centuries. The active hypoglycemic compound galegine was isolated early in the 20th century. Metformin (dimethyl biguanide) was first synthesiz...

Is vitamin D the most powerful anti cancer supplement?  Thousands of studies have been done on the health effects of vitamin D, and research shows it is involved in the biology of all the cells and tissues in your body, including your immune cells. Your cells actually need the active form of vitamin D to gain access to the genetic blueprints stored inside. This is one of the reasons why vitamin D has the ability to impact such a wide variety of health problems — from fetal development to cancer. Note: There are more than 12,000 search results on  vitamin D and cancer on PubMed .  2025 Study: Vitamin D Helps Lower Your Risk of Colorectal Cancer A comprehensive analysis published in the journal  Nutrients in April 2025  has discovered a fascinating but substantial link between vitamin D and colorectal cancer (CRC). The researchers reviewed and analyzed data from 50 separate studies involv...