Top 10 Selling Cancer Drugs of 2024

By Editorial Team
  1. Keytruda - $22 billion
  2. Darzalex - $9 billion
  3. Opdivo - $7 billion
  4. Imbruvica - $5billion
  5. Tagrisso - $5 billion
  6. Revlimid - $4 billion
  7. Verzenio - $4 billion
  8. Imfinzi - $4 billion
  9. Ibrance - $3 billion
  10. Tecentriq - $3 billion
In the constantly evolving field of oncology, several cancer drugs have emerged as best-sellers due to their effectiveness in treating various types of cancer. Below, we explore some of the top-selling cancer drugs, detailing their FDA-approved indications, mechanisms of action, and sales figures.



1. Keytruda (Pembrolizumab) - $7.3 billion

Indications Approved by FDA:
    • Non-small cell lung cancer (NSCLC)
    • Melanoma
    • Head and neck squamous cell carcinoma (HNSCC)
    • Classical Hodgkin lymphoma
    • Urothelial carcinoma
    • Gastric cancer
    • Esophageal cancer
    • Triple-negative breast cancer (TNBC)
    • Renal cell carcinoma (RCC)
    • Microsatellite instability-high (MSI-H) cancers
    • Colorectal cancer
    • Hepatocellular carcinoma (HCC)
    • Cervical cancer
Mechanism of Action: Keytruda is a monoclonal antibody that targets the programmed death-1 (PD-1) receptor on T cells. By binding to PD-1, it prevents the interaction between PD-1 and its ligands, PD-L1 and PD-L2, which are often overexpressed on cancer cells. This blockade reactivates T cells, allowing them to recognize and attack cancer cells.

2. Darzalex (Daratumumab) - $5.6 billion

Indication Approved by FDA: Multiple myeloma.

Mechanism of Action: Darzalex is a monoclonal antibody that targets CD38, a glycoprotein expressed on the surface of multiple myeloma cells. By binding to CD38, Darzalex induces tumor cell death through multiple mechanisms, including complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and antibody-dependent cellular phagocytosis. It also modulates the immune system to attack the cancer cells.

3. Opdivo (Nivolumab) - $4.5 billion

Indications Approved by FDA:
  • NSCLC
  • Melanoma
  • RCC
  • HNSCC
  • Urothelial carcinoma
  • Classical Hodgkin lymphoma
  • Hepatocellular carcinoma
  • Esophageal squamous cell carcinoma
  • Gastric cancer
  • Colorectal cancer with MSI-H/dMMR
  • Small cell lung cancer (SCLC)
Mechanism of Action: Opdivo is another immune checkpoint inhibitor that targets the PD-1 receptor on T cells. Like Keytruda, it blocks the PD-1/PD-L1 interaction, enhancing the immune system's ability to recognize and destroy cancer cells.

4. Tagrisso (Osimertinib) - $3.2 billion

  • Indications Approved by FDA:

    • EGFR T790M mutation-positive NSCLC

    • First-line treatment of metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations

  • Mechanism of Action: Tagrisso is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It selectively inhibits both EGFR sensitizing mutations and the T790M resistance mutation, which is a common cause of resistance to earlier-generation EGFR TKIs. By blocking these mutations, Tagrisso inhibits cancer cell proliferation and induces apoptosis.


5. Revlimid (Lenalidomide) - $3.0 billion

  • Indications Approved by FDA:

    • Multiple myeloma

    • Mantle cell lymphoma

    • Myelodysplastic syndromes (MDS)

    • Follicular lymphoma

  • Mechanism of Action: Revlimid is an immunomodulatory drug that has multiple mechanisms of action, including direct anti-proliferative effects on tumor cells, inhibition of angiogenesis, and immune system modulation. It also enhances T-cell and natural killer (NK) cell-mediated cytotoxicity and reduces the production of pro-inflammatory cytokines.



6. Verzenio (Abemaciclib) - $2.4 billion

  • Indications Approved by FDA:

    • HR-positive, HER2-negative advanced or metastatic breast cancer

  • Mechanism of Action: Verzenio is an oral, selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). By inhibiting CDK4/6, Verzenio prevents the phosphorylation of the retinoblastoma protein (Rb), leading to cell cycle arrest at the G1 phase, thereby inhibiting the proliferation of cancer cells.


7. Imfinzi (Durvalumab) - $2.3 billion

  • Indications Approved by FDA:

    • Unresectable stage III NSCLC

    • Extensive-stage small cell lung cancer (ES-SCLC)

    • Urothelial carcinoma

  • Mechanism of Action: Imfinzi is a monoclonal antibody that targets PD-L1, a ligand for PD-1. By binding to PD-L1, Imfinzi prevents it from interacting with PD-1 on T cells, thereby restoring immune responses and allowing the immune system to attack the cancer.


8. Ibrance (Palbociclib) - $2.2 billion

  • Indications Approved by FDA:

    • HR-positive, HER2-negative advanced or metastatic breast cancer

  • Mechanism of Action: Ibrance is an oral CDK4/6 inhibitor, similar to Verzenio. It works by inhibiting CDK4/6, which leads to cell cycle arrest in the G1 phase. This action reduces cancer cell proliferation, particularly in HR-positive breast cancer.


9. Perjeta (Pertuzumab) - $1.9 billion

  • Indications Approved by FDA:

    • HER2-positive breast cancer

  • Mechanism of Action: Perjeta is a monoclonal antibody that targets the HER2 receptor, a protein that is overexpressed in some breast cancers. Perjeta binds to a different epitope on HER2 than Herceptin (trastuzumab), allowing for a more comprehensive blockade of HER2 signaling. This dual inhibition results in a more potent suppression of tumor growth.



10. Tecentriq (Atezolizumab) - $1.8 billion

  • Indications Approved by FDA:

    • NSCLC

    • SCLC

    • Urothelial carcinoma

    • Triple-negative breast cancer (TNBC)

    • Hepatocellular carcinoma (HCC)

  • Mechanism of Action: Tecentriq is a monoclonal antibody that targets PD-L1, similar to Imfinzi. By blocking the PD-L1/PD-1 interaction, Tecentriq reactivates T cells to detect and destroy cancer cells.



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