10 Best Supplements to Fight Cancer: Evidence Based Literature Review (2024)
The term anti-cancer supplements can be a little misleading. Some supplements may help reduce a person’s risk of developing cancer or support the body during cancer treatment.
Anyone considering taking vitamins and supplements during cancer treatment should seek advice from their doctor first, particularly as some can interact with other medications or cause side effects.
- Best Anti Cancer Supplements
- Vitamin D3 and K2
- Fish Oil (Omega-3 Fatty Acids)
- Vitamin C, E and Selenium
- Turmeric (Curcumin)
- Magnesium
- Green tea (EGCG)
- Quercetin
- Melatonin
- Garlic (Allicin)
- Molecular Hydrogen
- Diet and Cancer Prevention
- Cancer Fighting Foods
- Don't use tobacco
- Alcohol and Cancer
- Maintain a healthy weight and be physically active
- Avoid risky behaviors
- Sleep Quality, Stress and Desk Job
- Protect yourself from the sun
- Get regular medical care and Health Screening
- Avoid unnecessary exposure to radiation.
- Avoid exposure to environmental toxins and infections that contribute to cancer
Cancer and supplements
When it comes to cancer of any kind, it’s important to realize that no dietary supplement can fully treat or cure cancer, according to BreastCancer.org. However, there are some supplements that can potentially help prevent cancer or assist in your cancer recovery.Best Cancer Fighting Supplements
1. Vitamin D3 and K2
The cancers for which the most human data are available are colorectal, breast, prostate, and pancreatic cancer. Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer (R). In contrast, the Women’s Health Initiative randomized trial found that healthy women who took vitamin D and calcium supplements for an average of 7 years did not have a reduced incidence of colorectal cancer (NEJM 2006). Some scientists have pointed out that the relatively low level of vitamin D supplementation (10 μg, or 400 IU, once a day), the ability of participants to take additional vitamin D on their own, and the short duration of participant follow-up in this trial might explain why no reduction in colorectal cancer risk was found.
- fatty fish
- egg yolks
- fortified milk
2. Fish Oil (Omega-3 Fatty Acids)
The research was presented April 4, 2022 at the annual Experimental Biology meeting in Philadelphia. The animal model showed that omega-3 fatty acids helped promote the cancer-fighting activities of immunotherapy and anti-inflammatory therapy.
Make sure you buy high-quality omega-3 fatty acid supplements, meaning that the omega-3 fatty acids are pure and have not oxidized much (having low “TOTOX” value).
TOTOX value stands for total oxidation value. The omega 3 fatty acids EPA and DHA from fish oil are highly sensitive to oxidation. This means that they are rapidly affected by contact with oxygen. Oxidised fatty acids are not beneficial to our health. For this reason, a good fish oil supplement has a low TOTOX value. The maximum TOTOX value is set at 26 by the Global Organization for EPA and DHA omega-3.
3. Vitamin C, E and Selenium
*Umbrella review: An umbrella review, or a review of reviews, is a systematic review that only considers other systematic reviews as an eligible study type for inclusion.
There's still no evidence that vitamin C alone can cure cancer, but researchers are studying whether it might boost the effectiveness of other cancer treatments, such as chemotherapy and radiation therapy, or reduce treatment side effects.
There are still no large, controlled clinical trials that have shown a substantial effect of vitamin C on cancer, but some preliminary studies do suggest there may be a benefit to combining standard treatments with high-dose IV vitamin C."
4. Turmeric (Curcumin)
- blocking cancer cells from multiplying
- killing colon, breast, prostate, and melanoma cancer cells
- slowing tumor growth
Unfortunately, while there's some curcumin in whole turmeric, there's not enough in the regular spice to achieve clinically relevant results. The turmeric root itself contains only about 3% curcumin concentration. Another major limitation of curcumin as a therapeutic agent is that it is poorly absorbed. When taken in its raw form, you're only absorbing about 1% of the available curcumin.
"Studies on the effect of curcumin on cancer and normal cells will be useful for the ongoing preclinical and clinical investigations on this potential chemo-preventive agent."
5. Magnesium and Cancer
An analysis of the prospective, Swedish Mammography Cohort (JAMA 2005), evaluated 61,433 women aged 40 to 75 without a history of cancer for a mean follow-up of 14.8 years. The highest quintile of magnesium intake was associated with a significantly lower risk of CRC compared with the lowest quintile. This benefit was observed for both colon and rectal cancers.
A case-control study evaluated 2204 subjects from the Tennessee Colorectal Polyp Study (2007), which demonstrated that increasing total magnesium intake was significantly associated with decreasing risk of CR.. The highest tertile of dietary magnesium intake (>298 mg/day) was significantly associated with reduced risk of CRC in an age-adjusted model.
A study of 140,601 postmenopausal women from the Women’s Health Initiative (2015) with an mean follow-up of 13 years demonstrated a significant reduction in CRC risk with the highest quintile of total magnesium intake compared with the lowest quintile of magnesium intake. The benefit was driven by colon cancer, with a trend for rectal cancer.
Pancreatic Cancer
A study of 66,806 subjects aged 50 to 76 at baseline from the Vitamins and Lifestyle cohort (Nature 2015) evaluated magnesium intake and the incidence of pancreatic cancer during a mean follow-up of 6.8 years. Subjects with magnesium intake below the recommended dietary allowance were more likely to develop pancreatic cancer, particularly in those whose intake was less than 75% of the recommended dietary allowance. In this study, a 100 mg/day decrease in magnesium intake resulted in a 24% increase in risk of pancreatic cancer.
6. Melatonin
7. Green Tea (EGCG)
However, the National Center for Complementary and Integrative Health (NCCIH) state that studies of green tea and cancer in humans have so far produced inconsistent results.
8. Quercetin
2022 - A paper published in August 2022 in Nutrition Research analyzed the pro-apoptotic effect that quercetin has on aging cells. The paper reviewed preclinical and early phase data using quercetin as a senolytic agent and found the data showed it was effective in “preventing or alleviating cancer formation.”
The authors reviewed the importance of cellular aging in the development of cancer cells and the effect that quercetin may have on the suppression of cancer cell proliferation.
Cellular senescence is a dynamic and multi-step process that is associated with alterations in metabolic activity and gene expression. This can compromise tissue regeneration and contribute to aging. On the other hand, by removing senescent cells, age-related dysfunction can be attenuated and potentially extend the lifespan.
This study published in 2017 in Oncology Reports took things a step further, finding that quercetin induced cancer cell death in nine types of cancer, including prostate cancer, colon cancer, and breast caner.
In another 2017 study, researchers gave quercetin to mice with tumors. Researchers found that mice in the quercetin-treated group showed delayed tumor growth, no significant changes in daily behavior, significantly better survival ratings, and increased rates of cell death.
9. Garlic (Allicin) and Onion
One study of 543,220 participants found that those who ate lots of Allium vegetables, such as garlic, onions, leeks and shallots, had a lower risk of stomach cancer than those who rarely consumed them (Source).
A study of 471 men showed that a higher intake of garlic was associated with a reduced risk of prostate cancer (Source).
Several clinical studies have found an association between garlic intake and a lower risk of certain types of cancer.
10. Molecular Hydrogen and Cancer
Diet and Cancer Prevention
Randomized controlled trials (RCTs) of dietary interventions aimed at preventing cancer, conversely, are expensive and largely impractical. Therefore, most current evidence concerning diet and cancer prevention is derived from observational epidemiologic studies, in particular prospective cohort studies, mechanistic studies of food components in laboratory animals and cell culture, and RCTs when available.
- Eat plenty of fruits and vegetables. Base your diet on fruits, vegetables and other foods from plant sources — such as whole grains and beans. Eat lighter and leaner by choosing fewer high-calorie foods. Limit refined sugars and fat from animal sources.
- Drink alcohol only in moderation, if at all. Alcohol increases the risk of various types of cancer, including cancer of the breast, colon, lung, kidney and liver. Drinking more increases the risk.
- Limit processed meats. Eating processed meat often can slightly increase the risk of certain types of cancer. This news comes from a report from the International Agency for Research on Cancer, the cancer agency of the World Health Organization.
A large study that involved 79,952 US-based men found that those who ate the largest amounts of healthy plant-based foods had a 22% lower risk of bowel cancer compared with those who ate the least.
The researchers found no such link for women, of whom 93,475 were included in the research. The team suggested that the link is clearer for men, who have an overall higher risk of bowel cancer. Their findings were published in the journal BMC Medicine (Nov 2022).
Intermittent fasting or prolonged fasting refers to periods of restricted calorie intake or complete food avoidance. Like the Ketogenic diet, fasting triggers the use of ketones as the predominant energy source and may sensitize cancer cells to treatments and potentially slow down tumor growth. Fasting-induced metabolic changes may also favor the protection of normal tissues from therapy side effects and improve tolerance and quality of life impacts to care.
Cancer Fighting Foods
But research shows that a diet filled with a variety of vegetables, fruits, whole grains, beans and other plant foods helps lower risk for many cancers. In laboratory studies, many individual minerals, vitamins and phytochemicals demonstrate anti-cancer effects. By including more foods that fight cancer into your diet, you will help reduce your risk of developing cancer.
Do take note that we are talking about foods to prevent your risk of cancer and not about treating cancer with foods. Cancer treatments will be something that you will need to discuss with your cancer specialist.
Many foods contain beneficial compounds that could help decrease the growth of cancer. There are also several studies showing that a higher intake of certain foods could be associated with a lower risk of the disease.
We will delve into the research and look at a list of foods that may lower your risk of cancer.
Tomato (Lycopene)
Broccoli
Including broccoli with a few meals per week may come with some cancer-fighting benefits.
However, keep in mind that the available research hasn’t looked directly at how broccoli may affect cancer in humans.
Instead, it has been limited to test-tube, animal and observational studies that either investigated the effects of cruciferous vegetables, or the effects of a specific compound in broccoli. Thus, more human studies are needed.
Citrus Fruits
One large study found that participants who ate a higher amount of citrus fruits had a lower risk of developing cancers of the digestive and upper respiratory tracts (Source).
A review looking at nine studies also found that a greater intake of citrus fruits was linked to a reduced risk of pancreatic cancer (Source).
Finally, a review of 14 studies showed that a high intake, or at least three servings per week, of citrus fruit reduced the risk of stomach cancer by 28% (Source).
These studies suggest that including a few servings of citrus fruits in your diet each week may lower your risk of developing certain types of cancer.
Keep in mind that these studies don’t account for other factors that may be involved. More studies are needed on how citrus fruits specifically affect cancer development.
Olive Oil
Swapping out other oils in your diet for olive oil is a simple way to take advantage of its health benefits. You can drizzle it over salads and cooked vegetables, or try using it in your marinades for meat, fish or poultry.
Though these studies show that there may be an association between olive oil intake and cancer, there are likely other factors involved as well. More human studies are needed to look at the direct effects of olive oil on cancer in people.
Nuts
For instance, a study looked at the diets of 19,386 people and found that eating a greater amount of nuts was associated with a decreased risk of dying from cancer (Br J Nutr. 2015).
Another 2015 study followed 30,708 participants for up to 30 years and found that eating nuts regularly was associated with a decreased risk of colorectal, pancreatic and endometrial cancers (Source).
Other studies have found that specific types of nuts may be linked to a lower cancer risk. For example, Brazil nuts are high in selenium, which may help protect against lung cancer in those with a low selenium status (Source).
These results suggest that adding a serving of nuts to your diet each day may reduce your risk of developing cancer in the future.
Still, more studies in humans are needed to determine whether nuts are responsible for this association, or whether other factors are involved.
Carrots
For example, an analysis looked at the results of five studies and concluded that eating carrots may reduce the risk of stomach cancer by up to 26% (Source).
Another study found that a higher intake of carrots was associated with 18% lower odds of developing prostate cancer (Source).
One study analyzed the diets of 1,266 participants with and without lung cancer. It found that current smokers who did not eat carrots were three times as likely to develop lung cancer, compared to those who ate carrots more than once per week (Source).
Try incorporating carrots into your diet as a healthy snack or delicious side dish just a few times per week to increase your intake and potentially reduce your risk of cancer.
Still, remember that these studies show an association between carrot consumption and cancer, but don’t account for other factors that may play a role.
Berries
In one human study, 25 people with colorectal cancer were treated with bilberry extract for seven days, which was found to reduce the growth of cancer cells by 7% (Source).
Another small study gave freeze-dried black raspberries to patients with oral cancer and showed that it decreased levels of certain markers associated with cancer progression (Source).
One animal study found that giving rats freeze-dried black raspberries reduced esophageal tumor incidence by up to 54% and decreased the number of tumors by up to 62% (Source).
Similarly, another animal study showed that giving rats a berry extract was found to inhibit several biomarkers of cancer (Source).
Based on these findings, including a serving or two of berries in your diet each day may help inhibit the development of cancer. Keep in mind that these are animal and observational studies looking at the effects of a concentrated dose of berry extract, and more human research is needed.
Beans
One study followed 1,905 people with a history of colorectal tumors, and found that those who consumed more cooked, dried beans tended to have a decreased risk of tumor recurrence (Source).
According to these results, eating a few servings of beans each week may increase your fiber intake and help lower the risk of developing cancer.
Soy
lower risk of breast cancer. Tofu (bean curd), is a popular food derived from soy in Asia.
A review of 35 studies (Plos One. 2014) found that soy intake could lower the risk of breast cancer for both pre- and post-menopausal women in Asian countries. However, for women in Western countries, pre- or post-menopausal, there is no evidence to suggest an association between intake of soy isoflavone and breast cancer.
Garlic and Onion
These are rich in sulfur compounds, which may have antibacterial, anti-inflammatory, and anti-cancer properties.Gut Microbes and Probiotics
Certain gut bacteria also promote inflammation, which is an underlying factor in virtually all cancers, whereas other bacteria quell it. The presence of certain gut bacteria has even been shown to boost the patient's response to anticancer drugs. (Nature 2018)
One way in which gut bacteria improve the effectiveness of cancer treatment is by activating your immune system and allowing it to function more efficiently. Researchers have actually found that when these specific microbes are absent, certain anticancer drugs may not work at all.
Don't use tobacco
But it's not only smoking that's harmful. Chewing tobacco has been linked to cancer of the mouth, throat and pancreas.
Staying away from tobacco — or deciding to stop using it — is an important way to help prevent cancer. For help quitting tobacco, ask a health care provider about stop-smoking products and other ways of quitting.
Alcohol
Maintain a healthy weight and be physically active
Being at a healthy weight might lower the risk of some types of cancer. These include cancer of the breast, prostate, lung, colon and kidney.Physical activity counts too. Besides helping control weight, physical activity on its own might lower the risk of breast cancer and colon cancer.
Doing any amount of physical activity benefits health. But for the most benefit, strive for at least 150 minutes a week of moderate aerobic activity or 75 minutes a week of hard aerobic activity.
You can combine moderate and hard activity. As a general goal, include at least 30 minutes of physical activity in your daily routine. More is better.
Fasting and Cancer
Fasting may help reduce obesity-associated cancers. “There’s a lot of obesity-associated cancers,” said Dr. Jason Fung, a nephrologist and fasting expert. “There’s about 13 cancers that are well accepted that they are associated with obesity; fasting might help decrease that.”Fasting can potentially starve cancer cells. When fasting, the body uses fats and produces ketones for energy. Cancer cells rely heavily on glucose, making them less efficient at using ketones.
Additionally, fasting reduces insulin levels. Elevated insulin levels are linked to an increased risk of breast, prostate, and colorectal cancers.
Avoid risky behaviors
Another effective cancer prevention tactic is to avoid risky behaviors that can lead to infections that, in turn, might increase the risk of cancer. For example:
Practice safe sex. Limit the number of sexual partners and use a condom. The greater the number of sexual partners in a lifetime, the greater the chances of getting a sexually transmitted infection, such as HIV or HPV.
People who have HIV or AIDS have a higher risk of cancer of the anus, liver and lung. HPV is most often associated with cervical cancer, but it might also increase the risk of cancer of the anus, penis, throat, vulva and vagina.
- Don't share needles. Injecting drugs with shared needles can lead to HIV, as well as hepatitis B and hepatitis C — which can increase the risk of liver cancer. If you're concerned about drug misuse or addiction, seek professional help.
Protect yourself from the sun
Skin cancer is one of the most common kinds of cancer and one of the most preventable. Try these tips:
- Avoid midday sun. Stay out of the sun between 10 a.m. and 4 p.m. when the sun's rays are strongest.
- Stay in the shade. When outdoors, stay in the shade as much as possible. Sunglasses and a broad-brimmed hat help too.
- Cover your skin. Wear clothing that covers as much skin as possible. Wear a head cover and sunglasses. Wear bright or dark colors. They reflect more of the sun's harmful rays than do pastels or bleached cotton.
- Don't skimp on sunscreen. Use a broad-spectrum sunscreen with an SPF of at least 30, even on cloudy days. Apply a lot of sunscreen. Apply again every two hours, or more often after swimming or sweating.
- Don't use tanning beds or sunlamps. These can do as much harm as sunlight.
Sleep, Stress and Desk Job
The American Cancer Society has also found a link between long periods of inactivity and cancer. The group says that people who spend "prolonged leisure time sitting" — defined as more than 6 hours per day — have a 19% higher rate of death compared to people who sit an average of 3 hours per day. That number includes all causes of death, but it doesn't necessarily mean that sitting directly causes cancer or other diseases, since sick people are also likely to move around less.
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