Top 10 Cancer Fighting Supplements: Evidence Based Literature Review (2025)
Are you overwhelmed by conflicting advice on cancer, diet, and supplements? You’re not alone. With so many claims out there, it’s hard to separate fact from fiction.
A 2023 systematic review and meta-analysis of 14 RCTs
(randomized controlled trials), published in Ageing Research
Reviews (Kuznia 2023) found vitamin D3 supplementation reduced cancer mortality by
6%. This wasn’t considered statistically significant, but when
only studies involving daily vitamin D intake were analyzed,
cancer mortality dropped by a significant 12%.
*Note: "Death from anything" may be a clearer term for the
layperson as opposed to 'All-cause mortality'. This is one of
the best measures for the factors that increase the risk of
what eventually and most likely will take someone's life.
Many experts now recommend 800 to 1,000 IU a day, a goal
that's nearly impossible to attain without taking a
supplement.
Vitamin K2: A wonder nutrient against cancer
A disorder previously nicknamed “pre-leukemia” called Myelodysplastic syndrome (MDS) often leads to full-blown leukemia, with all its disastrous consequences. In MDS, the bone marrow churns out young white blood cells instead of mature ones. But vitamin K treatment can induce apoptosis, and cause MDS cells to differentiate into healthy, mature white blood cells that can help your immune response, even in the face of full-blown leukemia. (source)
Vitamin K2 combined with vitamin D3 may be even better. In a recent study, it more than doubled the response rate of patients with low white blood counts, boosting it from 13 percent to 30 percent.
Vitamin K may also help against non-Hodgkin lymphoma, stomach, nasopharynx, and oral cancers. (source)
The first randomized-controlled trial to investigate the combination of three complementary treatments for the prevention of cancer and suggest that the combination of daily vitamin D3, supplemental marine omega-3s, and a simple home exercise program may be effective in the prevention of invasive cancer among generally healthy and active adults aged 70 and older.
Findings from a study performed in mice, research from Harvard Medical School’s Beth Israel Deaconess Medical Center in Boston demonstrated omega-3 fat could reduce tumor growth by 67% (R).
The research was presented April 4, 2022 at the annual Experimental Biology meeting in Philadelphia. The animal model showed that omega-3 fatty acids helped promote the cancer-fighting activities of immunotherapy and anti-inflammatory therapy.
Flax seed is rich in omega-3 fatty acids, which may reduce the risk of certain cancers. When supplementing, try to avoid flaxseed oil because it lacks the nutrients of ground flax seed. Ground flax seed can be purchased online or found in many larger grocery store chains. Simply sprinkle some ground flax seed on your food and enjoy.
Make sure you buy high-quality omega-3 fatty acid supplements, meaning that the omega-3 fatty acids are pure and have not oxidized much (having low “TOTOX” value).
TOTOX value stands for total oxidation value. The omega 3 fatty acids EPA and DHA from fish oil are highly sensitive to oxidation. This means that they are rapidly affected by contact with oxygen. Oxidised fatty acids are not beneficial to our health. For this reason, a good fish oil supplement has a low TOTOX value. The maximum TOTOX value is set at 26 by the Global Organization for EPA and DHA omega-3.
*Umbrella review: An umbrella review, or a review of reviews, is a systematic review that only considers other systematic reviews as an eligible study type for inclusion.
2022 - A meta-analysis to review the association between vitamins and brain cancer showed that intake of vitamin C, β-carotene, and folate can reduce the risk of brain cancer, while high serum α-tocopherol (vitamin E) concentration also has a protective effect on brain cancer.
High-dose vitamin C cancer therapy was introduced by Linus Pauling and Ewan Cameron [R]. Clinical demonstration results by Pauling and Cameron showed that intravenous injection of 10 g/day of vitamin C extended the survival time of terminal cancer patients by about 4.2 times. However, results from the Mayo Clinic in 1979 showed that the survival time of vitamin C–treated patients was even shorter than that of the placebo group patients [R]. A significant difference between those two research groups was the route of AA administration: intravenous injection and oral administration, respectively.
"More recently, vitamin C given through a vein (intravenously) has been found to have different effects than vitamin C taken in pill form. This has prompted renewed interest in the use of vitamin C as a cancer treatment.
There's still no evidence that vitamin C alone can cure cancer, but researchers are studying whether it might boost the effectiveness of other cancer treatments, such as chemotherapy and radiation therapy, or reduce treatment side effects.
There are still no large, controlled clinical trials that have shown a substantial effect of vitamin C on cancer, but some preliminary studies do suggest there may be a benefit to combining standard treatments with high-dose IV vitamin C."
Vitamin C as a cancer therapy has had a controversial past. What has been intriguing are small clinical trials that suggest some responses, but with no clear rationale for why cancers should respond to vitamin C or a path forward for explaining which patients are most likely to respond. Now a growing number of preclinical studies are showing how high-dose vitamin C might benefit cancer patients. Importantly, these preclinical studies provide a clear rationale and potential biomarkers that may help personalize the therapeutic approach and identify patient populations that are likely to respond to high-dose vitamin C therapy. Since the mechanisms of action of vitamin C are becoming better defined, we can propose vitamin C combinations in a more rational, hypothesis-driven manner. In addition, given the current high financial cost of new cancer drugs, it seems rational to improve the effectiveness of current therapies by studying their clinical interactions with vitamin C. In our view, the implementation of this treatment paradigm could provide benefit to many cancer patients.
Several studies have demonstrated an association between high magnesium intake and reduced risk of colorectal cancer (CRC).
An analysis of the prospective, Swedish Mammography Cohort (JAMA 2005), evaluated 61,433 women aged 40 to 75 without a history of cancer for a mean follow-up of 14.8 years. The highest quintile of magnesium intake was associated with a significantly lower risk of CRC compared with the lowest quintile. This benefit was observed for both colon and rectal cancers.
A case-control study evaluated 2204 subjects from the Tennessee Colorectal Polyp Study (2007), which demonstrated that increasing total magnesium intake was significantly associated with decreasing risk of CR.. The highest tertile of dietary magnesium intake (>298 mg/day) was significantly associated with reduced risk of CRC in an age-adjusted model.
A study of 140,601 postmenopausal women from the Women’s Health Initiative (2015) with an mean follow-up of 13 years demonstrated a significant reduction in CRC risk with the highest quintile of total magnesium intake compared with the lowest quintile of magnesium intake. The benefit was driven by colon cancer, with a trend for rectal cancer.
Magnesium and Pancreatic Cancer
A study of 66,806 subjects aged 50 to 76 at baseline from the Vitamins and Lifestyle cohort (Nature 2015) evaluated magnesium intake and the incidence of pancreatic cancer during a mean follow-up of 6.8 years. Subjects with magnesium intake below the recommended dietary allowance were more likely to develop pancreatic cancer, particularly in those whose intake was less than 75% of the recommended dietary allowance. In this study, a 100 mg/day decrease in magnesium intake resulted in a 24% increase in risk of pancreatic cancer.
A 2020 study in Japan administered hydrogen therapy to 42 patients with stage-four lung cancer. The researchers found that hydrogen therapy could extend the overall survival of the patients. Specifically, patients receiving hydrogen therapy had a median survival time of 28 months, almost triple the survival time of those undergoing immunotherapy.
Note: Most Molecular Hydrogen tablets uses pure elemental magnesium as its carrier and provides you with approximately 80 mg of magnesium per tablet. So, you receive also highly bioavailable magnesium for a healthy brain, muscles, cells, kidneys, and heart.
Melatonin is also known to play a fundamental role in
regulating the sleep-wake rhythm; however, in the last 10
years it has been discovered that it is actually involved
in many other biological mechanisms, also playing an
important role in the inflammatory, metabolic and
neoplastic processes. In fact, the mechanisms by which
melatonin performs an anti-tumor effect are many: it has
an anti-oxidant effect that protects against DNA damage,
acts as a scavenger of reactive oxygen species (which
undermine genomic stability), stimulates DNA repair
mechanisms, improves the functioning of the mitochondrial
respiratory chain, and inhibits mitochondrial mitophagy
and telomerase activity (Molecules 2018).
Reduction of melatonin production has also been seen in
some types of cancer (breast and prostate) (Mogavero 2021).
2022 - An umbrella review of meta-analyses based on
randomized controlled trials (Pharmacological Research 2022):
"Survival at one year (P < 0.005) significantly
increased with cancer patients."
"All trials included solid tumor cancers. All trials
were conducted at the same hospital network, and were
unblinded. Melatonin reduced the risk of death at 1 yr
(relative risk: 0.66). Effects were consistent across
melatonin dose, and type of cancer. No severe adverse
events were reported. The substantial reduction in
risk of death, low adverse events reported and low
costs related to this intervention suggest great
potential for melatonin in treating cancer."
2022 - A paper published in August 2022 in Nutrition Research analyzed the pro-apoptotic effect that quercetin has on aging cells. The paper reviewed preclinical and early phase data using quercetin as a senolytic agent and found the data showed it was effective in “preventing or alleviating cancer formation.”
The authors reviewed the importance of cellular aging in the development of cancer cells and the effect that quercetin may have on the suppression of cancer cell proliferation.
Cellular senescence is a dynamic and multi-step process that is associated with alterations in metabolic activity and gene expression. This can compromise tissue regeneration and contribute to aging. On the other hand, by removing senescent cells, age-related dysfunction can be attenuated and potentially extend the lifespan.
According to a 2018 review, EGCG and green tea extracts may help prevent or delay cancer onset, cancer recurrence, and secondary growths from cancer.
However, the National Center for Complementary and Integrative Health (NCCIH) state that studies of green tea and cancer in humans have so far produced inconsistent results.
Green tea also contains chemicals called polyphenols that have antioxidant, anti-inflammatory properties and anti-angiogenic properties, and the catechins in green tea polyphenols show very strong anti-angiogenic properties.
Some studies show health benefits in people who drink as little as one cup per day, while other studies deem five or more cups per day to be optimal (Source, Source).
The study was conducted on the basis of the Shandong
Intervention Trial, a randomized, placebo-controlled,
factorial-designed trial (1995-2003) in a
well-recognized high-risk area for GC in China.
Participants were continuously followed up to December
2017 for 22.3 y (1995-2017). A total of 3,229 subjects
were included.
One study of 543,220 participants found that those who ate lots of Allium vegetables, such as garlic, onions, leeks and shallots, had a lower risk of stomach cancer than those who rarely consumed them (Source).
A study of 471 men showed that a higher intake of garlic was associated with a reduced risk of prostate cancer (Source).
Related: Garlic, the ‘King of Cancer Prevention’
Additionally, a systematic review and meta-analysis published in Nutrients in 2022 established a 16 percent increase in lung cancer risk associated with beta-carotene supplementation, with smokers and asbestos workers facing an even greater risk of 21 percent.
The U.S. Preventive Services Task Force (USPSTF) recommends against using beta-carotene supplementation for the prevention of cardiovascular disease (CVD) or cancer.
The USPSTF found 6 randomized clinical trials (RCTs) reporting on health outcomes associated with beta carotene supplementation (JAMA 2022). Two trials conducted in persons who smoke or were exposed to asbestos in the workplace found a significantly increased risk of lung cancer with beta carotene supplementation (NEJM 1994) and beta carotene plus vitamin A supplementation (NEJM 1996).
A study published in 2023 by Newcastle University in the UK found that eating more carrots is related to a reduced incidence of cancer, but taking beta-carotene had no such effect.
Vitamin E
The USPSTF does not recommend using vitamin E supplements to prevent CVD or cancer, citing a comprehensive analysis of nine randomized trials that demonstrated no benefits.
Although vitamin E is a good antioxidant, too much of it can cause gastrointestinal bleeding and other conditions, Dr. Tzung-Hai Yen, a professor in the Department of Nephrology and director of the Clinical Poison Center at Chang Gung Memorial Hospital in Taiwan, told The Epoch Times.
This is especially the case for people with chronic diseases, Yen said. They need to be more cautious because many health products might not suit them. They should first seek advice from a physician before taking vitamin E supplements.
Vitamin B in High Doses
“Some people take them [vitamins and supplements] because they automatically assume that vitamins and supplements only have positive health benefits, but very little is known about how they actually work,” Elena Goun, an associate professor of chemistry at University of Missouri said. “Because of this lack of knowledge, we were inspired to study the basic questions surrounding how vitamins and supplements work in the body.”
Can certain foods lower your cancer risk? Are some foods increasing it without you realizing? What about vitamin and mineral supplements—do they help prevent cancer, or could they actually increase your risk?
The term "anti-cancer supplements" can be misleading. While some nutrients support the body in cancer prevention or treatment, others may interfere with therapies or even pose risks.
This guide compiles over 300 scientific references on cancer, diet, and supplements—helping you navigate the facts with confidence.
Understanding Supplements and Cancer: What You Should Know
- Dietary supplements are not regulated like medications. Unlike prescription drugs, supplements aren’t rigorously tested by the FDA for safety or effectiveness before hitting the market.
- Not all supplements are beneficial. While some may support health, others could interact with cancer treatments or cause unwanted side effects.
- Choosing the right supplement can be overwhelming. With thousands of options available, knowing where to start can be a challenge.
Should You Take Supplements During Cancer Treatment?
If you're considering supplements, always consult your doctor first—especially since some may interfere with medications or ongoing treatments.
How to Interpret Scientific Research
Not all studies carry the same weight. Here’s how research ranks in terms of credibility:
- Meta-analysis and systematic reviews – The highest level of evidence, as they analyze and combine data from multiple RCTs and studies to identify overall trends and draw more reliable conclusions.
- Randomized controlled trials (RCTs) – The gold standard, providing the strongest evidence.
- Small human studies – Can offer insights, but results are less reliable.
- Animal studies (mice/rat models) – A step closer to understanding effects in living organisms.
- Lab studies (cell cultures) – Useful for early discoveries but not directly applicable to humans.
Related: Hallmarks of Cancer: What You Need to Know
What This Article Covers
We’ll explore dietary supplements that may help prevent cancer or aid recovery during treatment, along with the latest research and studies. New findings emerge constantly, so staying informed is key.
Let’s dive into the science and separate the myths from the facts!
Contents:
- Top 10 Cancer Fighting Supplements
- Vitamin D3 and K2
- Turmeric (Curcumin)
- Fish Oil (Omega-3 Fatty Acids)
- Vitamin C
- Magnesium and Molecular Hydrogen
- Green tea (EGCG)
- Quercetin
- Melatonin
- Garlic (Allicin)
- Vitamin E
- 3 Supplements That May Increase Cancer Risk
- Nicotinamide riboside supplements and Cancer
- Conclusion
While many vitamins and minerals can benefit your general health,
there’s a huge market of unregulated supplements that may provide
no added benefit to your health. Certain supplements even have the
potential to negatively impact cancer treatments. This is because
some supplements can counteract medications or medical therapies.
If you’re thinking about supplementing your diet with anti-cancer
vitamins, always talk to your doctor first.
 |
| Credit: FLCCC Alliance |
We have organised and summarised relevant and salient research
information in one place. Below, we look at the most published and
studied categories.
Here is the list (listed in order of importance):
1. Vitamin D3 and K2
Is vitamin D the most powerful anti cancer supplement? Vitamin D can absorb calcium and help the immune, muscle, and
nervous systems function properly. There are more than 12,000
search results on vitamin D and cancer on PubMed.
In another 2023 meta-analysis, 116 randomised controlled trials (RCTs) were analysed. The meta-analysis concluded that
vitamin D reduces lung cancer mortality.
The first randomized-controlled trial (DO-HEALTH) trial to
investigate the combination of three complementary
treatments for the prevention of cancer and suggest that the
combination of daily vitamin D3, supplemental marine
omega-3s, and a simple home exercise program may be
effective in the prevention of invasive cancer among
generally healthy and active adults aged 70 and older.
Findings from a 3 year Randomized Controlled Trial with
more than 2,000 participants observed a 61% reduction in
the risk of invasive cancer among patients who completed a
home exercise program and took vitamin D3 and omega-3 fatty acids daily. These results, from
the DO-HEALTH trial, were published in Frontiers in Aging 2022.
A number of epidemiologic studies have also investigated
whether people with higher vitamin D intakes or higher blood
levels of vitamin D have lower risks of specific cancers.
The results of these studies have been inconsistent,
possibly because of the challenges in carrying out such
studies. For example, dietary studies do not account for
vitamin D made in the skin from sunlight exposure, and the
level of vitamin D measured in the blood at a single point
in time (as in most studies) may not reflect a person’s true
vitamin D status. Also, it is possible that people with
higher vitamin D intakes or blood levels are more likely to
have other healthy behaviors. It may be one of these other
behaviors, rather than vitamin D intake, that influences
cancer risk.
The cancers for which the most human data are available are colorectal, breast, prostate, and pancreatic cancer. Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer (R). In contrast, the Women’s Health Initiative randomized trial found that healthy women who took vitamin D and calcium supplements for an average of 7 years did not have a reduced incidence of colorectal cancer (NEJM 2006). Some scientists have pointed out that the relatively low level of vitamin D supplementation (10 μg, or 400 IU, once a day), the ability of participants to take additional vitamin D on their own, and the short duration of participant follow-up in this trial might explain why no reduction in colorectal cancer risk was found.
The cancers for which the most human data are available are colorectal, breast, prostate, and pancreatic cancer. Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer (R). In contrast, the Women’s Health Initiative randomized trial found that healthy women who took vitamin D and calcium supplements for an average of 7 years did not have a reduced incidence of colorectal cancer (NEJM 2006). Some scientists have pointed out that the relatively low level of vitamin D supplementation (10 μg, or 400 IU, once a day), the ability of participants to take additional vitamin D on their own, and the short duration of participant follow-up in this trial might explain why no reduction in colorectal cancer risk was found.
According to BreastCancer.org, research suggests that certain cancers such as breast cancer, can have a higher risk of occurring when the body has low levels of vitamin D.
Studies also show a link between vitamin D deficiency and cardiovascular disease, diabetes, and cancer (Sizar, 2020).
In 2016, a landmark study published in PLOS ONE found that women over 55 with blood concentrations of vitamin D higher than 40 ng/ml, had a 67% lower risk of cancer compared women with levels lower than 20 ng/ml.
Studies also show a link between vitamin D deficiency and cardiovascular disease, diabetes, and cancer (Sizar, 2020).
In 2016, a landmark study published in PLOS ONE found that women over 55 with blood concentrations of vitamin D higher than 40 ng/ml, had a 67% lower risk of cancer compared women with levels lower than 20 ng/ml.
Although the role of vitamin D in cancer
prevention remains an area of research interest
and debate, avoiding deficient levels is
recommended. (American Cancer Society 2020)
Vitamin D can also be absorbed through sunlight,
or with the following diet:
- fatty fish
- egg yolks
- fortified milk
The Optimal Vitamin D Level for Cancer Prevention
Research has shown that once you reach a minimum serum vitamin D level of 40 ng/mL (100 nmol/L), your risk for cancer diminishes by a whopping 67%, compared to having a level of 20 ng/mL or less.
Research has shown that once you reach a minimum serum vitamin D level of 40 ng/mL (100 nmol/L), your risk for cancer diminishes by a whopping 67%, compared to having a level of 20 ng/mL or less.
Make sure to take 500 mg to 1000 mg of magnesium and 150
mcg of vitamin K2, (not K1) which are important
cofactors for optimizing vitamin D function. And,
remember the only way you know what your vitamin D level
is, is to test it. Vitamin D level should be in a
therapeutic range of 50 to 70 ng/ml for treatment of
rheumatoid arthritis. Most people are shocked how low
their level is when they finally get around to testing
it.
You'll also want to ensure you're following an overall
healthy lifestyle to reduce your cancer risk as much as
possible.
Recommendation: Target a Vitamin D level of 50-70
ng/mL.
Caution: The dosage for vitamin D
in prevention (1,000 to 2,000 IU
daily) is very much different from the high
dose treatment dosage i.e. 20,000 to
50,000 IU daily. Always consult your doctor
first!
A large German study of 24,340 adults ages 35 to 64 showed that the quartile (one-fourth of the participants) consuming the most vitamin K2 were 28 percent less like to die from colon, breast, prostate, or lung cancers than those in the lowest quartile of consumption. (This was after factoring in things like age, weight, exercise, and the like.)
The connection was strongest for lung and prostate cancers.
There’s more: A study published in the International Journal of Oncology found that cancer cells grow more slowly in lung cancer patients treated with vitamin K2.
A previous study found the same effect with leukemia patients. Vitamin K2 also safely suppressed growth of hepatocellular carcinoma, a common and deadly type of liver cancer, by blocking cell replication and triggering apoptosis. (source)
The connection was strongest for lung and prostate cancers.
There’s more: A study published in the International Journal of Oncology found that cancer cells grow more slowly in lung cancer patients treated with vitamin K2.
A previous study found the same effect with leukemia patients. Vitamin K2 also safely suppressed growth of hepatocellular carcinoma, a common and deadly type of liver cancer, by blocking cell replication and triggering apoptosis. (source)
Related: Vitamin K1 vs K2
Vitamin K also slashed the risk of liver cancer coming back, in a group of patients who had experienced remission. Here’s the story. . .
Sixty-one liver cancer patients were declared free of cancer following surgery. Thirty-two of them received a vitamin K2 analogue, whereas 29 received placebos. The cumulative survival rates for the patients who received menatetrenone were 100% at 12 months, 96.6% at 24 months, and 87.0% at 36 months; and the corresponding survival rates for patients in the control group were 96.4%, 80.9%, and 64.0%, respectively (P = 0.051). (source)
Vitamin K also slashed the risk of liver cancer coming back, in a group of patients who had experienced remission. Here’s the story. . .
Sixty-one liver cancer patients were declared free of cancer following surgery. Thirty-two of them received a vitamin K2 analogue, whereas 29 received placebos. The cumulative survival rates for the patients who received menatetrenone were 100% at 12 months, 96.6% at 24 months, and 87.0% at 36 months; and the corresponding survival rates for patients in the control group were 96.4%, 80.9%, and 64.0%, respectively (P = 0.051). (source)
A disorder previously nicknamed “pre-leukemia” called Myelodysplastic syndrome (MDS) often leads to full-blown leukemia, with all its disastrous consequences. In MDS, the bone marrow churns out young white blood cells instead of mature ones. But vitamin K treatment can induce apoptosis, and cause MDS cells to differentiate into healthy, mature white blood cells that can help your immune response, even in the face of full-blown leukemia. (source)
Vitamin K2 combined with vitamin D3 may be even better. In a recent study, it more than doubled the response rate of patients with low white blood counts, boosting it from 13 percent to 30 percent.
Vitamin K may also help against non-Hodgkin lymphoma, stomach, nasopharynx, and oral cancers. (source)
Caution: Vitamin K2 can interfere with blood thinners, so discuss K2 with your doctor if you’re taking these medications. If you’re pregnant or nursing, stay below the RDA for K2 (65 mcg).
Buying Guide: Most vitamin D3 supplements include vitamin K2. Click here to buy vitamin D3 and K2.
Buying Guide: Most vitamin D3 supplements include vitamin K2. Click here to buy vitamin D3 and K2.
2. Turmeric (Curcumin)
Curcumin is one of the nutrients with the most evidence-based
literature supporting its use against cancer. There are more than
7,000 search results on curcumin and cancer on PubMed and more than 50 clinical trials with curcumin, most of which are still ongoing. The spice
turmeric can be extremely helpful when it comes to fighting
cancer.
Interestingly, curcumin appears to be universally useful for just
about every type of cancer (Arslan 2022), which is really odd since cancer consists of a wide variety of
different molecular pathologies.
In a 2016 study, a team of scientists at the University of Pittsburgh and at
Pondicherry University, India, discovered the bioactive
ingredient in turmeric, curcumin, can both prevent and cure
bowel cancers. The team found the compound triggered cancer cell
death by increasing a level of protein labeled GADD45a. Lead
author Rajasekaran Baskaran, Ph.D., who has more than 20 years
of experience in cancer research, commented:
"Studies on the effect of curcumin on cancer and normal cells will be useful for the ongoing preclinical and clinical investigations on this potential chemo-preventive agent."
Studies show that the curcumin in turmeric may kill cancer cells and
slow tumor growth. This preclinical research has taken curcumin
from the lab to the clinic.
The benefits of curcumin may include:
- blocking cancer cells from multiplying
- killing colon, breast, prostate, and melanoma cancer cells
- slowing tumor growth
A review paper published in 2022, analysed 21 human studies. Sixteen
out of 21 clinical trials were associated with the
effectiveness of curcumin or turmeric on various types of
cancer, and the other five clinical trials were related to
the evaluation of the efficacy of curcumin or turmeric in
relieving the side effects of cancer chemotherapy and
radiotherapy. The emerging data from the clinical trials
confirm that curcumin has the potential for cancer
prevention and intervention.
Both curcuminoids and related turmeric products have been
sanctioned by the U.S. Food and Drug Administration (FDA) as
safe.
Why Whole Turmeric Is Ineffective
Unfortunately, while there's some curcumin in whole turmeric, there's not enough in the regular spice to achieve clinically relevant results. The turmeric root itself contains only about 3% curcumin concentration. Another major limitation of curcumin as a therapeutic agent is that it is poorly absorbed. When taken in its raw form, you're only absorbing about 1% of the available curcumin.
Unfortunately, while there's some curcumin in whole turmeric, there's not enough in the regular spice to achieve clinically relevant results. The turmeric root itself contains only about 3% curcumin concentration. Another major limitation of curcumin as a therapeutic agent is that it is poorly absorbed. When taken in its raw form, you're only absorbing about 1% of the available curcumin.
Because it's not easily absorbed through your gastrointestinal
tract, it's more effective to use a high-quality bioavailable
curcumin extract, according to a 2013 study. A typical anticancer dose is just under 1 teaspoon of
curcumin extract three or four times daily.
However, in the case of colon cancer, this poor absorption
into the bloodstream may be an advantage. As there is poor
absorption, higher levels of curcumin stay in the intestinal
tract for longer periods of time, having an effect on
gastrointestinal cancers.
In one study, participants took a 1,080 milligram (mg) dose per day of
curcumin for 10 to 30 days between their initial biopsy and
surgical removal. The patients taking the supplement
experienced a reduction in blood levels of inflammatory agent,
improvement in their body weight and an increased number of
dying tumor cells.
"Studies on the effect of curcumin on cancer and normal cells will be useful for the ongoing preclinical and clinical investigations on this potential chemo-preventive agent."
New Curcumin Forms
Convenience and efficiency has driven many of the changes in
the forms of curcumin in later years. Because it's a
fat-loving or lipophilic molecule, many newer preparations now
include some sort of oil or fat, which improves its
absorbability and bioavailability. Such preparations typically
have seven to eight times higher absorption than the raw,
unprocessed 95% concentration of dry powder. There are also
newer sustained release preparations.
Turmeric and black pepper each have health benefits, due to
the compounds curcumin and piperine. As piperine enhances
curcumin absorption in the body by up to 2,000%, combining the
spices magnifies their effects. (Healthline)
Buying Guide: Click here to buy Bioavailable Curcumin
3. Fish Oil (Omega-3 Fatty Acids)
PubMed has indexed more than 3,000 research studies on Omega-3 and cancer. Most people use fish oil supplements to enhance the amount of omega-3’s in their diet.
Findings from a 3 year Randomized Controlled Trial with more than 2,000 participants observed a 61% reduction in the risk of invasive cancer among patients who completed a home exercise program and took vitamin D3 and omega-3 fatty acids daily.
These results, from the DO-HEALTH trial (ClinicalTrials.gov identifier NCT01745263), were published in Frontiers in Aging 2022.
The research was presented April 4, 2022 at the annual Experimental Biology meeting in Philadelphia. The animal model showed that omega-3 fatty acids helped promote the cancer-fighting activities of immunotherapy and anti-inflammatory therapy.
Many governments recommend eating omega-3 containing fatty fish, two times per week. But that is often not enough. Ideally, people would need to eat fatty fish four times per week, while also supplementing with omega-3 fatty acids, at least 1,000 mg of pure omega-3 (DHA and EPA) per day.
However, fish oil was shown in one study on mice (2015) to possibly reduce the effectiveness of chemotherapy, and for that reason ground flax seed is a worthy alternative.
Make sure you buy high-quality omega-3 fatty acid supplements, meaning that the omega-3 fatty acids are pure and have not oxidized much (having low “TOTOX” value).
TOTOX value stands for total oxidation value. The omega 3 fatty acids EPA and DHA from fish oil are highly sensitive to oxidation. This means that they are rapidly affected by contact with oxygen. Oxidised fatty acids are not beneficial to our health. For this reason, a good fish oil supplement has a low TOTOX value. The maximum TOTOX value is set at 26 by the Global Organization for EPA and DHA omega-3.
Buying Guide: Click here to buy Omega-3.
4. Vitamin C
PubMed has indexed more than 3,000 research studies on vitamin C and cancer and more than 5,000 studies on vitamin E and cancer. United States Preventive Services Task Force has recommended the use of Vitamin C and E supplementation for cancer prevention (R).
Prevention
2022 - An umbrella review* (Xu 2022) to assess the existing systematic reviews and meta-analyses for the association between vitamin C intake and multiple health outcomes; showed that vitamin C intake was associated with reduced risk of all-cause mortality, cardiovascular disease (CVD), oesophageal cancer, gastric cancer, cervical cancer and lung cancer with an increment of 50–100 mg per day.
Beneficial associations were also identified for respiratory, neurological, ophthalmologic, musculoskeletal, renal and dental outcomes. A total of 76 meta-analyses (51 papers) of randomised controlled trials and observational studies with 63 unique health outcomes were identified. Harmful associations were found for breast cancer and kidney stones for vitamin C supplement intake.
*Umbrella review: An umbrella review, or a review of reviews, is a systematic review that only considers other systematic reviews as an eligible study type for inclusion.
2022 - Obese women who took vitamin C and B6 at amounts that exceeded the recommended daily intake levels were associated with a lower risk of breast cancer, according to a five-year long South Korean cohort study. 40,432 women without a history of cancer at baseline were included in this study.
A 2017 meta-analysis of 11 studies concluded that patients with lower concentrations of serum vitamin E (the vitamin E level in your blood) had a higher risk for colorectal cancer.
2023 - A systematic review to evaluate the existing literature on the safety and efficacy of vitamin C, E and selenium supplementation in oncology patients. Findings were generally favorable among the studies, and adverse effects of supplementation were limited. The review concluded that antioxidant supplements may provide benefits in reducing incidence or severity of treatment-induced side effects with limited risk for adverse effects.
Treatment
2022 - A systematic review on the effect of vitamins C and E on cancer survival showed improvement of survival and progression rates of cancers by vitamins C and E. However, the authors concluded that more high quality trials with large sample sizes are required to confirm.
Vitamin C is known as an antioxidant, but at high concentrations, vitamin C can kill cancer cells through a pro-oxidant property (Transl Oncol. 2020). This study has also demonstrated that vitamin C treatment with magnesium supplementation provided more effective anticancer therapy than vitamin C treatment alone.
To understand the mechanism of AA's anticancer activity, many research groups have treated colon, prostate, leukemia, lymphoma, brain, and stomach cancer cells and chemically or genetically transformed cancer cells with AA and showed cancer growth inhibition and even cancer cell death through hydrogen peroxide–mediated reactive oxygen species (ROS) generation [R]. In most cases, the pharmacological concentration of vitamin C required for anticancer effects (EC50 value of 1–10 mM) could only be achieved by intravenous administration. Thus, to apply vitamin C as an anticancer therapy, a high intracellular concentration in cancer cells is critically important (R).
According to the Mayo Clinic (2023):
There's still no evidence that vitamin C alone can cure cancer, but researchers are studying whether it might boost the effectiveness of other cancer treatments, such as chemotherapy and radiation therapy, or reduce treatment side effects.
There are still no large, controlled clinical trials that have shown a substantial effect of vitamin C on cancer, but some preliminary studies do suggest there may be a benefit to combining standard treatments with high-dose IV vitamin C."
According to the concluding remarks from a 2020 article from the National Cancer Institute:
Buying Guide: Click here to buy vitamin C and quercetin
5. Magnesium and Molecular Hydrogen
PubMed has indexed more than 5,000 research studies on magnesium and cancer.
Magnesium and Colorectal Cancer
An analysis of the prospective, Swedish Mammography Cohort (JAMA 2005), evaluated 61,433 women aged 40 to 75 without a history of cancer for a mean follow-up of 14.8 years. The highest quintile of magnesium intake was associated with a significantly lower risk of CRC compared with the lowest quintile. This benefit was observed for both colon and rectal cancers.
A case-control study evaluated 2204 subjects from the Tennessee Colorectal Polyp Study (2007), which demonstrated that increasing total magnesium intake was significantly associated with decreasing risk of CR.. The highest tertile of dietary magnesium intake (>298 mg/day) was significantly associated with reduced risk of CRC in an age-adjusted model.
A study of 140,601 postmenopausal women from the Women’s Health Initiative (2015) with an mean follow-up of 13 years demonstrated a significant reduction in CRC risk with the highest quintile of total magnesium intake compared with the lowest quintile of magnesium intake. The benefit was driven by colon cancer, with a trend for rectal cancer.
Magnesium and Pancreatic Cancer
A study of 66,806 subjects aged 50 to 76 at baseline from the Vitamins and Lifestyle cohort (Nature 2015) evaluated magnesium intake and the incidence of pancreatic cancer during a mean follow-up of 6.8 years. Subjects with magnesium intake below the recommended dietary allowance were more likely to develop pancreatic cancer, particularly in those whose intake was less than 75% of the recommended dietary allowance. In this study, a 100 mg/day decrease in magnesium intake resulted in a 24% increase in risk of pancreatic cancer.
Magnesium and Vitamin C
A 2020 study demonstrated that vitamin C treatment with magnesium supplementation provided more effective anticancer therapy than vitamin C treatment alone.
Molecular Hydrogen and Cancer
There is little evidence to show that molecular hydrogen can reduce the risk of cancer.
However, in terms of cancer treatment, studies involving the effects of H2 on cancer were systematically reviewed. More than 600 articles related to molecular hydrogen and cancer were retrieved from Cochrane, PubMed and Google Scholar, and 27 articles were included for this systematic review (2023).
Based on the authors' analysis, "H2 plays a promising therapeutic role as an independent therapy as well as an adjuvant in combination therapy, resulting in an overall improvement in survivability, quality of life, blood parameters, and tumour reduction."
Although H2 has demonstrated significant anti-cancer effects, the underlying mechanisms have not yet been elucidated. Many studies have shown that H2 therapy can reduce oxidative stress. This, however, contradicts radiation therapy and chemotherapy, in which ROS (Reactive Oxygen Species) are required to induce apoptosis and combat cancer.
Buying Guide: Best Molecular Hydrogen Tablets
6. Melatonin
PubMed has indexed more than 3,300 research studies
on melatonin and cancer.
The Mediterranean Diet (MD) dietary pattern is also rich
in antioxidants, such as melatonin. A systematic review
published in Antioxidants (Elena 2023) showed high melatonin contents in MD-related foods,
such as tomatoes, olive oil, red wine, beer, nuts, and
vegetables. The consumption of specific MD foods increases
melatonin levels and improves the antioxidant status in
plasma.
Melatonin is one of the most important antioxidant
molecules. In the human body — aside from having direct
antioxidant effects — it also stimulates the synthesis
of glutathione and other important antioxidants like
superoxide dismutase and catalase.
Many people are not aware that only 5% of your body’s
melatonin — which is also a potent anticancer agent — is
produced in your pineal gland. The other 95% is produced
inside your mitochondria — provided you get sufficient
near infrared exposure which is typically from sun on
your bare skin. This is why vitamin D is more than
likely a biomarker for sun exposure, which is
intricately involved in melatonin production. (R)
In addition, melatonin increases the expression of the
p53 protein, induces its phosphorylation, inhibiting
cell proliferation, promotes apoptosis, reduces the
levels of the vascular endothelial growth factor and
endothelin-1, fundamental for tumor growth and
metastasis formation, reduces inflammatory processes and
cell migration (Molecules 2018).
Melatonin - Treatment
2020 - A case series of 14 advanced cancer patients (Trends in Oncology 2020), treated with high dose (1,000 mg/day) of melatonin;
achieved a disease control of 54% of the patients:
"Moreover, this preliminary study may also suggest
that high dose melatonin has no toxicity in cancer
patients with poor clinical status, as well as in
healthy subjects."
2005 - A systematic review of 10 randomized
controlled trials (J Pineal Res 2005):
7. Quercetin
PubMed has indexed more than 4,000 research studies
on quercetin and cancer.
2022 - A paper published in August 2022 in Nutrition Research analyzed the pro-apoptotic effect that quercetin has on aging cells. The paper reviewed preclinical and early phase data using quercetin as a senolytic agent and found the data showed it was effective in “preventing or alleviating cancer formation.”
The authors reviewed the importance of cellular aging in the development of cancer cells and the effect that quercetin may have on the suppression of cancer cell proliferation.
Cellular senescence is a dynamic and multi-step process that is associated with alterations in metabolic activity and gene expression. This can compromise tissue regeneration and contribute to aging. On the other hand, by removing senescent cells, age-related dysfunction can be attenuated and potentially extend the lifespan.
2020 - Another paper (2020) identified some of the
anti-inflammatory, antioxidant and antiproliferative
properties quercetin has that enhances breast cancer
treatment, while another (2020) evaluated its effect on the treatment
of ovarian cancer, which is a serious cancer growth and
threat to women's health.
2019 - Research also has demonstrated that quercetin can promote
the loss of cell viability and autophagy through several
pathways, including those involving mitochondrial
function and glucose metabolism.
This study published in 2017 in Oncology Reports took things a step further, finding that quercetin induced cancer cell death in nine types of cancer, including prostate cancer, colon cancer, and breast caner.
This study published in 2017 in Oncology Reports took things a step further, finding that quercetin induced cancer cell death in nine types of cancer, including prostate cancer, colon cancer, and breast caner.
Quercetin affects endothelial (thin membrane lining
heart and blood vessels) cell proliferation, migration,
and angiogenesis. As an anti-angiogenic compound, it has
been shown to have a targeted effect on tumor
angiogenesis in both in vitro and in vivo experiments.
It has also been demonstrated in animal experiments that
quercetin can reduce angiogenesis.
In another 2017 study, researchers gave quercetin to mice with tumors. Researchers found that mice in the quercetin-treated group showed delayed tumor growth, no significant changes in daily behavior, significantly better survival ratings, and increased rates of cell death.
In another 2017 study, researchers gave quercetin to mice with tumors. Researchers found that mice in the quercetin-treated group showed delayed tumor growth, no significant changes in daily behavior, significantly better survival ratings, and increased rates of cell death.
Quercetin may also target bladder cancer. In 2016, researchers published a landmark study in the
American Journal of Cancer Research. Researchers
analyzed quercetin’s effect on cancer cells in a test
tube. They concluded, “We are the first to show that
quercetin displays potent inhibition on bladder cancer
cells via activation of AMPK pathway.”
According to Mount Sinai, quercetin should be used with caution as it may
interact with certain antibiotics by reducing the
effectiveness of the drug. It may also enhance the
effect of some blood thinners, which can increase your
risk of bleeding. In addition to these, it may interact
with corticosteroids, digoxin, cyclosporine and
fluoroquinolones.
Buying Guide: Click here to buy vitamin C and quercetin
8. Green Tea (EGCG)
PubMed has indexed more than 2,000 research studies on EGCG and cancer.
The Minnesota Green Tea Trial (MGTT. 2015) is the largest and longest double-blind, placebo-controlled, randomized intervention study that specifically evaluated the effects of oral GTE (green tea extract) containing defined quantities of EGCG on established biomarkers of breast cancer risk.
They randomized and stratified 1075 healthy postmenopausal women at high risk of breast cancer according to their breast tissue density and catechol-O-methyltransferase genotypes and divided them into two groups: 537 placebo and 538 green tea groups. Green tea group participants took 4 capsules that contained 843 mg EGCG, whereas the placebo group took capsules without green tea extracts.
Researchers measured changes in percent mammographic density, circulating endogenous sex hormones, and proteins of the insulin-like growth factor axis. Their results showed that supplementation with green tea extract could modify and reduce mammographic density (MD) and protect against breast cancer, even though it was only significant in younger women (50–55 years) and had no effect in older women (R), an age-dependent effect similar to those of tamoxifen.
However, the National Center for Complementary and Integrative Health (NCCIH) state that studies of green tea and cancer in humans have so far produced inconsistent results.
Several epidemiological studies (2011) have reported that the consumption of green tea may decrease cancer risk. Studies have also confirmed numerous health benefits of green tea including prevention of cancer (R, R) and cardiovascular disease, as well as anti-inflammatory, antioxidant, antiarthritic, antibacterial, and antiviral effects. (R, R, R, R).
If you have cancer, consider drinking up to 3 cups of green tea per day to experience the benefits. Green tea pills are also available, but may be too concentrated.
9. Garlic (Allicin) and Onion
PubMed has indexed more than 1,200 research studies
on garlic and cancer. Garlic and onions belong to the Allium genus of
plants.
2023 - A randomized controlled trial (RCT) on
garlic and gastric cancer (GC), published in January 2023, found a significant reduction in the risk of
developing GC with increasing dietary intake of
allium vegetables, particularly garlic
vegetables.
2020 - A meta-analysis of 11 studies,
published in January 2020, did find evidence that garlic could
reduce the risk of ColoRectal
Cancer.
Another study published in the Asia Pacific Journal of Clinical
Oncology (2019) revealed the odds of getting
ColoRectal Cancer were 79% lower in those
who a diet high in allium vegetables, which
include garlic, leeks and onions.
One study of 543,220 participants found that those who ate lots of Allium vegetables, such as garlic, onions, leeks and shallots, had a lower risk of stomach cancer than those who rarely consumed them (Source).
A study of 471 men showed that a higher intake of garlic was associated with a reduced risk of prostate cancer (Source).
Based on these findings, including 2–5 grams
(approximately one clove) of fresh garlic into
your diet per day can help you take advantage
of its health-promoting properties.
Several clinical studies have found an association between garlic intake and a lower risk of certain types of cancer.
Despite the promising results showing an
association between garlic and a reduced risk
of cancer, more studies are needed to examine
whether other factors play a role.
Garlic is a great choice when it comes
to giving your body a little extra
protection. To reap the benefits of garlic,
you should eat one clove per day,
or 300 to 1,000 milligrams (mg) of garlic extract.
The active component in garlic is
allicin, a compound that has been shown
to kill off cancer cells in multiple
test-tube studies (Source, Source, Source).
There is evidence demonstrating garlic can
kill cancer cells in vitro. Several
studies have analyzed the effects that
dietary garlic may have on the development
of colorectal cancer.
Several clinical studies have found an association between garlic intake and a lower risk of certain types of cancer.
10. Vitamin E
Vitamin E Is a Strong Antioxidant Fighting Aging and Cancer. PubMed has indexed more than 5,000 studies on vitamin E and cancer. United States Preventive Services Task Force has recommended the use of Vitamin C and E supplementation for cancer prevention (R).
Understanding the importance of antioxidants began as scientists learned how free radical damage was involved in the early stages of atherosclerosis and that free radical damage may be involved in a host of other chronic health conditions (R). Vitamin E plays a significant role as an antioxidant as it scavenges loose electrons and reduces cellular damage.
One of the benefits of lowering free radical damage is reducing skin damage after UV exposure. Vitamin E has been used in dermatology for more than 50 years and is added to cosmetic products (R). Additionally, the presence of vitamin C can slow lipid oxidation by regenerating alpha-tocopherol from radicals found in cell membranes (R).
Vitamin E is a major lipid-soluble antioxidant, protecting against oxidative stress in the epidermis and dermal layers of the skin. Data show that it has strong photoprotective and antiaging properties that help to improve elasticity and structure of the epidermis and dermis. Topical application has been widely used, after which vitamin E accumulates in the cell membranes and extracellular lipid matrix, where it contributes to antioxidant defenses (R).
In April 2022, researchers from MD Anderson Cancer Center9 published a paper in Cancer Discovery, in which they discuss data that show vitamin E may enhance cancer immunotherapy through a pathway that reinvigorates dendritic cells.
Dendritic cells have been a focus in cancer immunotherapy as they are critical in the immune response. Several strategies have been developed to target these cells in the hope that a better understanding of their function may help improve cancer therapies (R). The researchers found that an analysis of electronic health records showed patients who took vitamin E had significantly improved survival rates.
Recognizing that the impact of nutritional supplements in addition to immunotherapy is a relatively unexplored area, the researchers undertook an analysis of vitamin E and found that it blocks the activity of the SHP1 checkpoint, which in turn improves T cell ability to mount an antitumor immune response (R). Another 2020 study, looked at the benefits of using alpha-tocopherol in cancer prevention.
Researchers began with the understanding that those with a lower nutritional status had an increased risk of cancer and in some populations, supplementation had beneficial effects in lowering the risk. Other studies have focused on tocotrienol and the gamma and delta forms of tocopherols. While these three vitamin E compounds have a lower bioavailability, they appeared to have stronger cancer-preventive properties in animal models and cell lines.
One of the benefits of lowering free radical damage is reducing skin damage after UV exposure. Vitamin E has been used in dermatology for more than 50 years and is added to cosmetic products (R). Additionally, the presence of vitamin C can slow lipid oxidation by regenerating alpha-tocopherol from radicals found in cell membranes (R).
Vitamin E is a major lipid-soluble antioxidant, protecting against oxidative stress in the epidermis and dermal layers of the skin. Data show that it has strong photoprotective and antiaging properties that help to improve elasticity and structure of the epidermis and dermis. Topical application has been widely used, after which vitamin E accumulates in the cell membranes and extracellular lipid matrix, where it contributes to antioxidant defenses (R).
In April 2022, researchers from MD Anderson Cancer Center9 published a paper in Cancer Discovery, in which they discuss data that show vitamin E may enhance cancer immunotherapy through a pathway that reinvigorates dendritic cells.
Dendritic cells have been a focus in cancer immunotherapy as they are critical in the immune response. Several strategies have been developed to target these cells in the hope that a better understanding of their function may help improve cancer therapies (R). The researchers found that an analysis of electronic health records showed patients who took vitamin E had significantly improved survival rates.
Recognizing that the impact of nutritional supplements in addition to immunotherapy is a relatively unexplored area, the researchers undertook an analysis of vitamin E and found that it blocks the activity of the SHP1 checkpoint, which in turn improves T cell ability to mount an antitumor immune response (R). Another 2020 study, looked at the benefits of using alpha-tocopherol in cancer prevention.
Researchers began with the understanding that those with a lower nutritional status had an increased risk of cancer and in some populations, supplementation had beneficial effects in lowering the risk. Other studies have focused on tocotrienol and the gamma and delta forms of tocopherols. While these three vitamin E compounds have a lower bioavailability, they appeared to have stronger cancer-preventive properties in animal models and cell lines.
Buying Guide: Gamma E by Life Extension (Amazon)
Avoid Taking These 3 Supplements Too Casually as They May Increase Cancer Risk
Beta-Carotene
A meta-analysis published in Nutrition Reviews in 2023 analyzed eight randomized controlled trials and found that taking beta-carotene supplements showed no overall beneficial or harmful effects on cancer incidence but may increase lung cancer risk, particularly among smokers. Therefore, beta-carotene supplementation is not recommended for cancer prevention.
Additionally, a systematic review and meta-analysis published in Nutrients in 2022 established a 16 percent increase in lung cancer risk associated with beta-carotene supplementation, with smokers and asbestos workers facing an even greater risk of 21 percent.
A 2020 review study published in Antioxidants proposed that beta-carotene can be both an antioxidant and a pro-oxidant in the human body and that beta-carotene can exacerbate the carcinogenic effects of ultraviolet rays.
The U.S. Preventive Services Task Force (USPSTF) recommends against using beta-carotene supplementation for the prevention of cardiovascular disease (CVD) or cancer.
It's important to emphasize caution when it comes to these natural products. It wasn't long ago that, after finding that people who ate a diet rich in foods containing beta-carotene had a lower risk of lung cancer, researchers set out to study the potential effect of supplements of beta-carotene on risk. Unlike the reduced risk seen with dietary beta-carotene, however, beta-carotene in supplement form was associated with an increased risk of developing the disease.
A study published in 2023 by Newcastle University in the UK found that eating more carrots is related to a reduced incidence of cancer, but taking beta-carotene had no such effect.
Vitamin E
Vitamin E is an antioxidant, effective in eliminating free radicals, promoting anti-aging, and improving immunity. However, a randomized controlled trial found that vitamin E supplementation significantly increased the risk of prostate cancer in healthy men. More than 30,000 participants from the United States, Canada, and Puerto Rico took a daily dose of 400 IU of vitamin E for seven to 12 years, revealing a 17 percent higher risk of prostate cancer than the placebo group.
A study published in Cell in 2019 found that long-term supplementation of vitamin E and the antioxidant N-acetylcysteine may further promote lung cancer metastasis.
The USPSTF does not recommend using vitamin E supplements to prevent CVD or cancer, citing a comprehensive analysis of nine randomized trials that demonstrated no benefits.
Although vitamin E is a good antioxidant, too much of it can cause gastrointestinal bleeding and other conditions, Dr. Tzung-Hai Yen, a professor in the Department of Nephrology and director of the Clinical Poison Center at Chang Gung Memorial Hospital in Taiwan, told The Epoch Times.
This is especially the case for people with chronic diseases, Yen said. They need to be more cautious because many health products might not suit them. They should first seek advice from a physician before taking vitamin E supplements.
Vitamin B in High Doses
A large U.S. study found that men who took high-dose vitamin B6 (at least 20 mg/day) or B12 (at least 55μg/day) supplements had almost double the risk of lung cancer compared with those who did not take them.
A large study in the United States identified a correlation between high-dose vitamin B6 (at least 20 mg/day) and B12 (at least 55 μg/day) supplementation in men, nearly doubling their risk of lung cancer compared with non-users.
Published in the Journal of Clinical Oncology, this study involved 77,118 Americans aged 50 to 76 and found that men supplementing with either vitamin had a 30 to 40 percent increased risk, particularly among smokers.
However, there was no association between vitamin B6, B9 (folic acid), and B12 supplementation and lung cancer risk in women. Data showed that the participants’ intake of both B6 and B12 far exceeded the U.S. government’s recommended daily intake of 1.3 mg/day and 2.4 mcg/day.
Supporting evidence from a case-control study with 5,183 case-control pairs published in the International Journal of Cancer linked higher vitamin B12 levels with an increased overall lung cancer risk. The study also analyzed genetic data from 29,266 lung cancer cases and 56,450 controls and reached the same conclusion.
Published in the Journal of Clinical Oncology, this study involved 77,118 Americans aged 50 to 76 and found that men supplementing with either vitamin had a 30 to 40 percent increased risk, particularly among smokers.
However, there was no association between vitamin B6, B9 (folic acid), and B12 supplementation and lung cancer risk in women. Data showed that the participants’ intake of both B6 and B12 far exceeded the U.S. government’s recommended daily intake of 1.3 mg/day and 2.4 mcg/day.
Supporting evidence from a case-control study with 5,183 case-control pairs published in the International Journal of Cancer linked higher vitamin B12 levels with an increased overall lung cancer risk. The study also analyzed genetic data from 29,266 lung cancer cases and 56,450 controls and reached the same conclusion.
Nicotinamide riboside supplements and Cancer
Research from an international group of scientists and chemists also found that high levels of NR (nicotinamide riboside) could lead to an increased risk of developing cancer. A 2022 study by researchers at the University of Missouri found that taking nicotinamide riboside supplement may contribute to risks of brain cancer. The vitamin, called nicotinamide riboside, or NR for short, is a variant of B3. Taking the nutritional pill may lead to increased chances of breast cancer and brain metastasis, according to the study‘s results. Metastasis is when cancer cells spread through the body, causing multiple tumorous growths beyond an initial location.
Conclusion
When interpreting scientific studies, let’s remember that cell
culture results are trumped by mouse results. Mouse results are
trumped by human results. Case studies & small human trial
results are trumped by double-blind placebo controlled ones.
The best way to prevent cancer is by maintaining overall good health through a nutritious, whole-food diet rich in fruits and vegetables, along with a healthy lifestyle. No supplement can compensate for an unhealthy lifestyle, which includes physical inactivity, heavy smoking, excessive alcohol consumption, chronic stress, and obesity.
While there’s no silver bullet supplement, there are some
anti-cancer supplements on the market that may help you keep the
disease at bay or stop it from getting worse. Whether you’re
living with cancer, a survivor, or just concerned for your
health, talk to your doctor to determine the best treatment for you.
For more information on treatment, causes and prevention, screening,
and the latest research, check out this comprehensive resource page
(by cancer type): https://cancer.aestheticsadvisor.com/p/cancer-types-by-system.html.
RELATED:
I-PREVENT CANCER protocol: An Evidence-Based Guide to Cancer Prevention (2025 Edition)
Top 17 Alternative Cancer Treatments that Work: Evidence Based (2025 Edition)
Comments
Post a Comment