Evidence-Based Strategies for Cancer Prevention: I-Prevent Cancer Protocol (2025 Edition)

By Editorial Team

Abstract

Cancer remains a leading cause of mortality worldwide, with incidence rates projected to rise significantly in the coming decades. While advances in treatment have modestly improved survival, prevention through modifiable risk factors remains underemphasized. This review synthesizes current evidence on the role of diet, lifestyle, and dietary supplements in cancer prevention, drawing on systematic reviews, meta-analyses, and major guideline recommendations. The I-PREVENT CANCER protocol is introduced as a practical, evidence-based framework for reducing cancer risk.

Introduction

Despite trillions spent on cancer research, cancer still kills around 10 million people a year and is a leading cause of death globally. The incidence of common cancers such as breast, lung, and colon cancer is expected to increase by over 75% between 2022 and 2050. 

While treatment advances offer incremental improvements in survival, prevention strategies—particularly those related to diet and lifestyle—are under-utilised. Ladanie et al (JAMA 2020) showed that over the past fifteen years, new therapies have led to an overall survival improvement of 2.4 months, while Del Paggio et al (JAMA 2021) reported an improvement of 3.4 months over the past thirty years.

This review addresses the evidence supporting preventive measures, including dietary patterns, lifestyle modifications, and select supplements, and introduces the I-PREVENT CANCER protocol as a consumer-oriented guide.

Methodology

A comprehensive literature review was conducted, focusing on systematic reviews, meta-analyses, randomized controlled trials (RCTs), and major clinical guidelines published between 2000 and 2024. Over 1,000 studies were evaluated, with priority given to high-quality human evidence. The hierarchy of evidence was considered, with systematic reviews and meta-analyses weighted most heavily, followed by large-scale RCTs and observational studies.

Causes of Cancer: Theoretical Perspectives and Risk Factors

Cancer etiology is multifactorial, involving genetic, metabolic, and environmental components. Theories such as the metabolic theory, somatic mutation theory, cancer stem cell theory, and the recently proposed mitochondrial-stem cell connection (MSCC) highlight the complexity of carcinogenesis. The MSCC theory posits that impaired oxidative phosphorylation in stem cells may drive tumorigenesis, emphasizing the importance of metabolic and stem cell pathways.

Lifestyle and environmental factors—including diet, physical inactivity, obesity, smoking, and exposure to carcinogens—are major modifiable contributors to cancer risk. Standard therapies predominantly target genetic mutations but may not address underlying metabolic dysfunction or cancer stem cells, which are implicated in metastasis and recurrence.

Dietary Patterns and Cancer Prevention

1. American Cancer Society (ACS) Guidelines

The ACS recommends a lifelong healthy eating pattern characterized by:

  • High nutrient density foods supporting healthy body weight
  • Diverse vegetables (including dark green, red, orange, and legumes)
  • Whole fruits and whole grains

The ACS advises limiting:

  • Red and processed meats
  • Sugar-sweetened beverages
  • Highly processed foods and refined grains
2. Mediterranean and Plant-Based Diets


A 2024 review in Nutrients and an umbrella review in PLOS One (2024) support the Mediterranean and plant-based diets for cancer risk reduction. Key findings include:

  • Mediterranean diet adherence is associated with lower cancer risk.

  • Vegetarian and pescetarian diets reduce general and colorectal cancer risk compared to carnivorous diets.

  • High heme and total iron intake increase lung cancer risk, while phytoestrogen intake is protective.

  • Coffee and tea have a neutral effect on cancer risk.

Caution is advised for vegetarians and vegans regarding potential deficiencies in vitamin B12, K2, D, omega-3 fatty acids, and trace minerals.

3. Processed Foods and Sugar

A 2024 umbrella review in BMJ found direct associations between high intake of ultra-processed foods and increased risk of cancer, metabolic dysfunction, and all-cause mortality. Another umbrella review (BMJ 2023) and additional studies link high sugar intake, especially from sugar-sweetened beverages, to increased cancer risk, particularly breast cancer. Cancer cells exhibit elevated glucose uptake, supporting recommendations to limit dietary sugar.

4. Dietary Fiber

A 2023 umbrella review of over 100 studies indicates that high dietary fiber intake is associated with reduced risk of multiple cancers, including colorectal, breast, and endometrial cancers. Fiber likely exerts protective effects via modulation of gut microbiota, reduction of inflammation, and improved metabolic health.

Lifestyle Factors in Cancer Prevention

Key lifestyle recommendations include:

  • Smoking cessation

  • Maintaining a healthy weight

  • Regular physical activity

  • Stress reduction

  • Avoiding unnecessary radiation exposure

Additional preventive measures include ensuring quality sleep, regular medical care, and minimizing exposure to toxins, infections, and known carcinogens.

Evidence-Based Anti-Cancer Supplements

1. Vitamin D3

Low vitamin D status is associated with increased cancer risk and mortality. Supplementation may be beneficial, particularly in populations with documented deficiency.

2. Turmeric (Curcumin)

Curcumin exhibits anti-inflammatory and antioxidant properties, with preclinical evidence supporting anti-cancer effects. Human data are promising but require further validation.

3. Omega-3 Fatty Acids

Omega-3s may reduce inflammation and support metabolic health, with some evidence for reduced cancer risk, particularly colorectal cancer.

4. Vitamin C

High-dose vitamin C has been investigated as an adjunctive therapy, but robust evidence for cancer prevention in humans is lacking.

5. Green Tea Extract (EGCG)

Epidemiological and preclinical studies suggest protective effects, especially in gastrointestinal cancers.

6. Magnesium, Zinc, Probiotics, Garlic, Molecular Hydrogen

These supplements have varying levels of evidence, with some observational and mechanistic support for anti-cancer effects. Further research is needed to establish efficacy and optimal dosing.

Discussion

Current evidence supports a holistic approach to cancer prevention, emphasizing a plant-rich, minimally processed diet, regular physical activity, and avoidance of known carcinogens. Select dietary supplements may offer additional benefit, particularly in individuals with documented deficiencies or increased risk. The I-PREVENT CANCER protocol integrates these findings into a practical framework for consumers and healthcare providers.

Conclusion

The most effective way to reduce cancer risk is through a personalized, multi-faceted strategy that emphasizes overall health. This begins with a nutrient-dense, whole-food diet rich in fruits, vegetables, and fiber—while eliminating ultra-processed foods, added sugars, and harmful additives. Combined with a consistent, healthy lifestyle, these foundational habits form a powerful line of defense against cancer.

Each person’s biological makeup, lifestyle, and health status are unique—so prevention strategies should be, too. It’s crucial to empower yourself with accurate, science-backed medical knowledge, especially the kind that may not always be fully addressed by conventional oncology.

Cancer prevention should never rely on a single intervention. It demands a multi-modal approach—where dietary choices, physical activity, stress management, sleep quality, and environmental awareness work together to support immune function and cellular health. While these habits are scientifically validated to reduce cancer risk, no one diet or lifestyle change alone can eliminate that risk entirely.

Optimal prevention involves integration. Diet and lifestyle must be part of a broader, individualized strategy—potentially incorporating medical screenings, targeted supplementation, or additional therapeutic interventions. Since every body responds differently, a flexible and well-rounded plan offers the best chance for long-term protection.

For deeper insights, consult reliable resources such as the American Cancer Society, which provides research-based guidance on cancer prevention by type. For a broader look at causes, treatments, screening options, and prevention strategies categorized by cancer system, visit this detailed resource hub.

Whether you are navigating a current diagnosis, are in recovery, or simply taking proactive steps for your health, consult your healthcare provider to create a prevention or treatment plan that is safe, evidence-based, and tailored specifically for you. Ongoing research is essential to refine these recommendations and address remaining gaps in knowledge.

Key Takeaways

  • Prioritize a plant-based or Mediterranean diet, rich in fiber and low in processed foods and sugar.
  • Maintain a healthy lifestyle, including regular exercise, healthy weight, and avoidance of tobacco and excess alcohol.
  • Consider evidence-based supplementation for individuals at risk of deficiency.
  • Prevention strategies should be individualized and integrated into routine healthcare.

Source: AACR Cancer Progress Report 2024​

This paper is an abridged version of the more comprehensive article (with more than 1000 references). To read the full article, visit I-PREVENT CANCER protocol: An Evidence-Based Guide to Cancer Prevention (2025 Edition).


Cancer Care: The Role of Repurposed Drugs and Metabolic Interventions in Treating Cancer (2nd Edition)


Buy on Amazon

The FLCCC has provided a summary protocol of the key natural and alternative interventions (in order of priority) you can take in order to prevent and treat cancer (Chapter 3: ROLE OF REPURPOSED DRUGS AND METABOLIC INTERVENTIONS IN TREATING CANCER):
  1. Quit smoking. 
  2. Reduce or limit the use of alcohol. 
  3. Lose weight: adopt a healthy diet, manage insulin resistance, and follow a time-restricted eating plan. OneDayMD view: If you have cancer and you are under-weight, this is not for you.
  4. Avoid processed food and processed vegetable oils. 
  5. Avoid sugary beverages and pure fruit juices. 
  6. Limit consumption of red meat to no more than 3 portions/week. 
  7. Vitamin D3: 5000 u/day and adjusted according to vitamin D3 level.
  8. Omega 3 fatty acids: 2-4 g/day.
  9. Green tea catechins: 500-1000 mg/day. Green tea extract should be taken during/after a meal, rather than on an empty stomach. 
  10. Melatonin: 0.75–5 mg (extended/slow release) at night.
  11. Metformin: Metformin should be considered in anyone at high risk of cancer, whether their risk extends from diabetes, pre-diabetes, insulin resistance, chronic viral infection, smoking, or genetics. Requires doctor’s evaluation, approval, and prescription. (Suggested dose ranges from 250-2000 mg daily.) OneDayMD view: If you are not at 'high risk', stick to intervention no. 3.
  12. Regular aerobic exercise and resistance training 30 minutes/day (walking, home strength training, etc.). 
  13. Reduce stress (meditation, yoga, mindfulness exercises, etc.). 
  14. Get at least 8 hours of high-quality sleep (ensure adequate sleep hygiene). 
  15. Avoid known carcinogens. 

Disclaimer

Although this is a comprehensive guide, please do not consider this guide as personal medical advice, but as a recommendation for use with professional providers. Consult with your doctor and discuss with her/him.

Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most strategies are not 100% protective against cancer. It's a continuous struggle between the immune system and the cancer cells.

Comments

Post a Comment

Popular posts from this blog

Fenbendazole vs Ivermectin for Cancer: Differences and Which Is Better?

By Editorial Team
Image
Cancer patients are increasingly inquiring about the use of the anthelmintic drugs Fenbendazole (FenBen) and Ivermectin (IVM) as potential treatments for cancer. Notably, these patients typically fall into two distinct groups, neither of which represents the usual stage 1 or 2 cancer cases where conventional therapies often show promise. The first group consists of older men whose lung or prostate cancer has recurred. Having undergone conventional treatments previously without success, they express skepticism about its effectiveness this time around. The second, larger group comprises younger patients under 40 dealing with aggressive breast cancer, colorectal cancer, or lymphoma—forms of early-onset cancers that appear to lack the typical mutations observed in traditional cases. This article aims to delve into the differences between Fenbendazole and Ivermectin by examining their me...
Read more

Exploring Ivermectin, Mebendazole and Fenbendazole as Aggressive Cancer Treatments: Research, Protocols, and Controversies (2025)

By Editorial Team
Image
Fenbendazole and ivermectin, both antiparasitic drugs that have shown potential in cancer treatment through several mechanisms, such as slowing cancer cell growth and boosting the immune response.  Fenbendazole  is being studied for its ability to disrupt energy production in cancer cells, effectively hindering their growth.  Ivermectin , on the other hand, has been explored in combination with checkpoint inhibitors to boost the immune system's response to tumors—especially in challenging cases like triple-negative breast cancer. Introduction Cancer remains a leading cause of morbidity and mortality worldwide, with an increasing incidence of aggressive and treatment-resistant tumors such as triple-negative breast cancer (TNBC), pancreatic adenocarcinoma, and glioblastoma. Despite significant advances in targeted therapies and immunotherapies, many patients continue to face limited effective options, highlighting an urgent need for novel, affordable, and accessible treatme...
Read more

Top 10 Cancer Fighting Supplements: Evidence Based Literature Review (2025)

By Editorial Team
Image
Are you overwhelmed by conflicting advice on cancer, diet, and supplements ? You’re not alone. With so many claims out there, it’s hard to separate fact from fiction . Can certain foods lower your cancer risk ? Are some foods increasing it without you realizing? What about vitamin and mineral supplements —do they help prevent cancer, or could they actually increase your risk ? The term " anti-cancer supplements " can be misleading. While some nutrients support the body in cancer prevention or treatment, others may interfere with therapies or even pose risks. This guide compiles over 300 scientific references on cancer, diet, and supplements—helping you navigate the facts with confidence. Understanding Supplements and Cancer: What You Should Know Dietary supplements are not regulated like medications. Unlike prescription drugs, supplements aren’t rigorously tested by the FDA for safety or effectiveness before hitting the market. Not all supplements are beneficia...
Read more

Fenbendazole and Ivermectin for Cancer Case Series: Over 150 Case Reports (2025)

By Editorial Team
Image
Anecdotal reports and preliminary studies suggest that ivermectin and fenbendazole, both antiparasitic drugs, may have potential anticancer effects when used alongside other treatments.  Many people immediately dismiss the potential of ivermectin and fenbendazole when they learn it is “horse or dog medicine”. That initial reaction is overcome when genuine human success stories are told including the lack of serious side effects. The testimonials you are about to read are from individuals who have bravely shared their experiences in the hope of inspiring and uplifting others. These are raw human accounts, unfiltered by gatekeepers—not peer-reviewed studies—but they offer insights that may be valuable to those searching for options. However, we acknowledge that robust clinical trials are needed to provide more conclusive scientific evidence. Table of Contents: Editor's Preface Introduction Fenbendazole and Ivermectin Case Series Compilation (alphabetical) Breast Cancer Success Storie...
Read more

Fenbendazole Dosage for Cancer in Humans: Benefits, Risks, and Guidelines (2025)

By Editorial Team
Image
What is Fenbendazole? Fenbendazole is an anthelmintic drug commonly used to treat parasitic infections in animals. However, recent research and anecdotal reports suggest it may have potential anticancer properties in humans. How Does Fenbendazole Work for Cancer? Fenbendazole is believed to work by disrupting microtubules in cancer cells, leading to cell cycle arrest and apoptosis (cell death). Some studies suggest it may also modulate glucose metabolism, limiting cancer cell energy supply. Recommended Fenbendazole Dosage for Cancer in Humans The commonly referenced Joe Tippens Protocol suggests the following dosage: Potential Side Effects of Fenbendazole in Humans While generally considered safe, potential side effects may include: Gastrointestinal discomfort (nausea, diarrhea, bloating) Liver enzyme elevation (rare) Bone marrow suppression (rare) Safety and Precautions Medical Supervision: Always consult with a doctor, especially if combining with other treatments. Drug Interaction...
Read more

Fact Check: Can Ivermectin and Fenbendazole Help Treat Cancer?

By Editorial Team
Image
Ivermectin and fenbendazole, originally developed as antiparasitic drugs, are sparking hope in the fight against cancer, fueled by inspiring stories like those shared by actor  Mel Gibson on The Joe Rogan Experience , where he celebrated friends’ remarkable recoveries. While these medications aren’t yet standard cancer treatments, early research is uncovering exciting potential. Scientists are encouraged by promising lab studies and are calling for more clinical trials to confirm their effectiveness and ensure safe use in humans, paving the way for innovative, accessible therapies that could transform lives. Introduction and Context According to a January 22, 2025 fact-check article by AFP: "The anti-parasitic drugs ivermectin and fenbendazole are not currently recommended for cancer, but posts spread across social media touting the medications after actor  Mel Gibson claimed on the Joe Rogan Experience  that they cured his friends' cases of the disease. Oncology ex...
Read more

Eat These Foods to Starve Cancer Cells to Death (2025)

By Editorial Team
Image
Some people may not realize this, but many people have cancer cells in their bodies without presenting much danger. Fortunately, there are some common foods that can cut off cancer cell’s nutrient supply and starve them to death. Autopsies of individuals who died of trauma often reveal microscopic colonies of cancer cells , also known as in situ tumors. Some people call them “disease-free cancers.” For instance,  researchers  in Denmark performed autopsies on women aged 40 to 50, who  never  had cancer during their lifetime, and found that 39 percent of them had small cancerous lesions in their breasts. Only 1 percent of women in this age group would be diagnosed with breast cancer. Examination  of some men in their 60s showed that 46 percent of them had histological evidence of prostate cancer, which is consistent with the findings of the autopsy study. However, the prevalence of prostate cancer in men aged 60 to 70 is actually around 1 percent....
Read more

Fenbendazole and Metastatic Cancer: the 2021 Stanford University Case Series

By Editorial Team
Image
What is the "Stanford Fenbendazole Protocol"? I bet you've never heard of the "Stanford Fenbendazole Protocol" for treating Cancer. Yet, it exists. But it's heavily suppressed by search engines and mainstream Oncology, especially in the United States and Canada. In 2021 a group at Stanford University Medical Center, Department of Medicine, published a Case Series (Clin. Oncol. Case Rep 2021)* on a "forbidden" repurposed drug, Fenbendazole. *Note: Clinical Oncology Case Reports is a peer-reviewed International clinical and medical oncology and cancer research Journal. Clinical Oncology Case Reports (COCR) is a high-impact multidisciplinary journal focus on the area of clinical and medical investigation. They wrote about 3 cases of Stage 4 Cancer patients who self-treated and cured their cancers.   Case 1: 63 year old man with a Stage 4 Renal Cell Carcinoma (clear cell) , a 5.3cm mass and mets to pancreas and bone, failed 3 lines of chemo. He ...
Read more

Ivermectin to Treat Cancer in Humans (2024)

By Editorial Team
Image
Ivermectin is a widely used antiparasitic drug that's listed on the World Health Organization's essential medicines list 1   and approved by the U.S. Food and Drug Administration. In low- and middle-income countries, ivermectin is commonly used to treat parasitic diseases including onchocerciasis (river blindness), strongyloidiasis and other diseases caused by soil-transmitted helminthiasis, or parasitic worms. 2 The drug is also used to treat scabies and lice. It's estimated that the total number of ivermectin doses distributed is equal to one-third of the world's population and, as such, "ivermectin at the usual doses (0.2–0.4 mg/kg) is considered extremely safe for use in humans." 3 Ivermectin also has demonstrated antiviral and anti-inflammatory properties and made headlines for its potential role in treating COVID-19 4  — although much of the positive press has been censored and falsely labeled misinformation. 5  Now researchers are highlighting another p...
Read more