Top 17 Cancer Fighting Supplements: Evidence Based Literature Review (2026 Update)
Medically reviewed by Dr. Frank Yap, MD | Written by OneDayMD Editorial Team | Last updated October 2026 Quick Answer Of the 17 supplements reviewed here, the deepest human evidence supports vitamin D3 (with K2 and magnesium) , polysaccharide-K (PSK) from turkey tail as an add-on to chemotherapy in Japanese trials, berberine for preventing colorectal adenoma recurrence, omega-3 fatty acids , curcumin and green tea EGCG . Even these show mixed rather than uniformly positive results. Melatonin looked promising in small trials, but the largest randomized trial found no benefit in early-stage lung cancer. A few supplements, namely high-dose beta-carotene, vitamin E and long-term high-dose B6/B12 , have been linked to higher cancer risk in specific groups. No supplement replaces conventional cancer treatment, and antioxidant pills are generally discouraged during chemotherapy or radiotherapy unless your oncologist directs otherwise. This is educatio...