Melatonin, CBD Oil and Ozone Therapy in Stage 4 Triple Negative Breast Cancer: A Case Report (2026)

By Editorial Team

OZONE, MELATONIN, CBD OIL Testimonial (1) - 42 year old Italian woman with Stage 4 Triple Negative Breast Cancer achieves COMPLETE REMISSION!


Italian researchers are doing some serious Cancer Research, and are at least a decade ahead of every big Cancer Center in America.

STORY: 42 year old woman was diagnosed with Stage 1 Breast Cancer Triple Negative (TNBC) in 2017 and had surgery, chemo and radiation. She was found to have BRCA1 mutation. In 2019 she was diagnosed with Stage 4 Breast TNBC Lung and mediastinal lymph node metastases. (perfect example of failure of modern Oncology) Sep.2019 she started: Chemo (carboplatin and gemcitabine, stopped in Nov.2019 due to side effects (sorry chemo enthusiasts) Integrative Protocol: Melatonin, CBD, Ozone Therapy: Ozone (Rectal): 80ug/mL, 2.5ml/kg, 4 times per week for 3 months, followed by a 3 month break Melatonin, starting at 100mg/day and increasing the dose by 100mg every 3 days up to 2000mg/day (500mg tablets, 4 per day) CBD 200mg/day during the three month Ozone Therapy and 400mg/day during the three month breaks. RESULTS: Jan.2020 - CT showed reduction in lung nodules and lymph node volume Mar.2020 - She started Olaparib (Targeted Therapy) (stopped June 2023) Apr.2020 - CT showed further reduction of lymph node size July 2020 - She started Vitamin D 50,000IU once a week Apr.2021 - CT showed complete response, no detectable disease. Jan.2026 - She remains cancer free 5 years later! COMMENT: After 2 months of Melatonin + CBD + Ozone, lung nodules were no longer detectable and lymph nodes started to shrink. After 1.5 years, patient achieved a complete response. The antiproliferative and chemosensitizing effects of Melatonin and CBD have been extensively demonstrated in vitro and in vivo, including in breast cancer models. Ozone therapy has been reported to inhibit breast cancer cell growth and enhance chemotherapy efficacy in vitro. Combined use of CBD, MLT, and O2/O3 therapy recently demonstrated synergistic anticancer activity in preclinical models of PANCREATIC ductal adenocarcinoma.


Melatonin, CBD Oil and Ozone Therapy and Pancreatic Cancer - 2024 Italian paper

Here is the same combination but used in Pancreatic Cancer. 2024 Zeppa et al - In Vitro and In Vivo Effects of Melatonin-containing combinations in Human Pancreatic Ductal Adenocarcinoma. (3) Highlights: In Pancreatic Cancer, Melatonin has been extensively studied in terms of tumor growth inhibition, improvement in chemo efficacy and regulation of tumor-associated immune cells CBD reduces Pancreatic Cancer growth in vitro and in vivo and works synergistically with gemcitabine chemo O2/O3 (Ozone) therapy is an integrative approach for cancer patients because of its ability to reduce pain, fatigue, and musculoskeletal symptoms Ozone anti-tumor effects were reported in 1980 but haven’t been studied. This study aimed to assess anticancer effects of Melatonin combined with CBD and Ozone in vitro and in mouse model of Pancreatic Cancer. These data highlight that MLT + CBD, O2/O3, and their triple combination exert anticancer effects, halving tumor volume without inducing animal toxicity. Quadruple combination (with gemcitabine chemo) showed the most significant reduction in tumor volume on Day 40, and its efficacy was maintained at the endpoint. In this study, the chemo was needed for maximum cancer cell killing.


References:

  1. Aguzzi C et al - Integrative use of Cannabidiol, Melatonin, and Oxygen-Ozone Therapy in Triple Negative Breast Cancer in Lung and Mediastinal Metastases. Reports 2026.
  2. Makis W. Integrative use of Cannabidiol, Melatonin, and Oxygen-Ozone Therapy in Triple Negative Breast Cancer in Lung and Mediastinal Metastases. X.com 2026.
  3. Makis W. Melatonin, CBD Oil and Ozone Therapy and Pancreatic Cancer - 2024 Italian paper. X.com 2026.

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