The Cancer Advisor

Abstract Background: Stage 4 prostate cancer has a 5-year survival rate of ~34% with standard of care (SOC, e.g., androgen deprivation therapy [ADT], chemotherapy, Lu-177-PSMA-617). An optimized intervention combining repurposed drugs, supplements, diet/lifestyle, and SOC components may improve outcomes. Methods: We simulated a double-blind RCT with 10,000 patients (5,000 per arm) with non-BRCA-mutated stage 4 prostate cancer (70% mHSPC, 30% mCRPC), comparing an intervention arm (ivermectin 1.5–2 mg/kg/day 3 days/week, mebendazole 500–1,500 mg/day, metformin 1,700 mg/day, vitamin C 1 g/kg IV 3 times/week, vitamin D 5,000 IU/day, curcumin 1,000 mg/day, low-glycemic Mediterranean diet, exercise, MBSR, plus ADT/Lu-177-PSMA-617) to a placebo arm with SOC. Primary endpoint was overall survival (OS); secondary endpoints included progression-free survival (PFS), quality of life (QoL, EORTC QLQ-C30/PR25), PSA response (≥50% reduction), time to PSA progression, PSA nadir, and safety. A Monte Ca...

Can natural supplements influence the outcome of patients with pancreatic cancer? Find out the answers below. What are pancreatic enzymes? Pancreatic enzymes help break down fats, proteins and carbohydrates. A normally functioning pancreas secretes about 8 cups of pancreatic juice into the duodenum, daily. This fluid contains pancreatic enzymes to help with digestion and bicarbonate to neutralize stomach acid as it enters the small intestine. As of February 2023, there are more than 600 studies investigating pancreatic enzyme for pancreatic cancer on  clinicaltrials.gov . Good nutritional care improves outcomes and is critical for your quality of life. The  Pancreatic Cancer Action Network  strongly recommends that patients have access to pancreatic enzymes and see a registered dietitian. Types of Pancreatic Enzymes and Their Effects 1. Lipase Effects: Lipase works with bile from the liver to break down fat molecules so they can be absorbed and used by the body. Shortage ...

Cancer treatment is entering a bold new era, with 2025 shaping up to be a year of breakthroughs, hope, and innovation.  Despite  trillions spent on cancer research , cancer still  kills around 10 million people a year  and is a leading cause of death globally, according to the World Health Organization. Cancer research continues to advance at an unprecedented pace, with new treatments offering hope to millions of patients worldwide. From next-generation immunotherapies to repurposed drugs, here are the top 10 emerging cancer therapies that are changing the game—and could redefine survival for millions. 1. Immunotherapy as a Neoadjuvant Strategy Using immunotherapy before surgery or other treatments is gaining traction, with evidence that checkpoint inhibitors alone may be sufficient in some cases, potentially changing standard care protocols ( 4 ). Advances in immunotherapy continue to improve survival rates. Novel checkpoint inhibitors, CAR-T cell therapies, an...