Vitamin D to Ivermectin — A 2026 Cancer Prevention Framework
Quick Answer: The ROOT Protocol is a tiered, nutraceutical-based cancer-prevention framework developed by Dr. Paul Marik and Dr. Justus Hope. It begins with a three-agent foundation — green tea EGCG, curcumin, and vitamin D3 — and adds omega-3s, berberine, and sulforaphane in higher tiers. The top tier, Root 9, adds the prescription drugs celecoxib, ivermectin, and mebendazole, and is scoped by its own authors to people with hereditary cancer syndromes under specialist supervision, not general use. It is best understood as a supplement escalation ladder layered on top of the diet and lifestyle foundation described in OneDayMD's I-PREVENT Cancer Protocol . Medically reviewed and updated by the OneDayMD Editorial Team | Last updated July 11, 2026 Table of Contents 1. Why Cancer Prevention Needs a Systems-Level Rethink 2. The Metabolic Drivers Screening Doesn't Address 3. The ROOT Protocol: From 3 Agents to 9 4. Root 3 and Root 4: The Foundationa...