Cancer Advisor

Summary Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited effective therapies and poor survival, especially in stage 4 disease. Repurposing antiparasitic agents such as fenbendazole and ivermectin has garnered interest due to their demonstrated anti-cancer properties in preclinical studies. Methods: We reviewed and synthesized 35 detailed case reports from 2022 to 2026 documenting the clinical use of fenbendazole and ivermectin, alone or in combination with standard therapies, in patients with advanced pancreatic cancer. Tumor markers, imaging outcomes, and clinical responses were analyzed alongside mechanistic literature. Results: Across cases, patients exhibited marked reductions in CA19-9 tumor markers (often >70%), significant tumor shrinkage on imaging, and improved clinical status. Responses were observed even in chemotherapy-resistant and metastatic disease. Mechanistic studies support multiple anti-cancer effects of...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers worldwide. With a 5-year survival rate of only 13% (American Cancer Society, 2026 data) and dropping to 3% for metastatic disease, PDAC has seen little improvement in outcomes over the past decades. Late diagnosis, dense tumor stroma, and near-universal KRAS mutations (90-95% of cases) drive rapid resistance to standard chemotherapy. A new triple drug therapy for pancreatic cancer, detailed in a December 2025/January 2026 study published in Proceedings of the National Academy of Sciences (PNAS) by researchers at Spain’s National Cancer Research Centre (CNIO), has delivered unprecedented preclinical results: complete tumor eradication in multiple rigorous mouse models with no detectable recurrence for over 200 days. Understanding Pancreatic Cancer and the Role of KRAS Mutations PDAC originates in the pancreatic ducts and spreads aggressively. KRAS mutations lock cells into uncontrolled growth signa...