Top 10 Emerging Cancer Therapies to Watch in 2025

By Editorial Team
Cancer treatment is entering a bold new era, with 2025 shaping up to be a year of breakthroughs, hope, and innovation. From next-generation immunotherapies to repurposed drugs, here are the top 10 emerging cancer therapies that are changing the game—and could redefine survival for millions.
Top 10 Emerging Cancer Therapies to Watch in 2025

1. Immunotherapy as a Neoadjuvant Strategy

Using immunotherapy before surgery or other treatments is gaining traction, with evidence that checkpoint inhibitors alone may be sufficient in some cases, potentially changing standard care protocols4.

Advances in immunotherapy continue to improve survival rates. Novel checkpoint inhibitors, CAR-T cell therapies, and bispecific antibodies are expanding treatment options for hard-to-treat cancers like pancreatic and brain tumors.

2. Precision Oncology and Genomics

AI-driven analysis of tumor genetics and microenvironment is enabling highly tailored therapies that improve outcomes and reduce side effects, making precision medicine a cornerstone of modern oncology4.

3. Tumor-Infiltrating Lymphocyte (TIL) and TCR-Engineered Therapies

Following approvals in 2024, TIL and TCR therapies represent a major advance in immunotherapy for solid tumors, enabling the immune system to better recognize and attack cancer cells4.

4. Antibody-Drug Conjugates (ADCs)

ADCs deliver chemotherapy directly to cancer cells, minimizing side effects. In 2025, new ADCs are being developed and approved for a wider range of cancers, improving treatment precision and efficacy48.

5. Drugging the “Undruggable” Targets (KRAS, GPCRs)

Second-generation inhibitors targeting challenging oncogenes like KRAS G12D and G12V are showing promising clinical results, expanding treatment options for cancers previously considered difficult to target4.

6. Molecular Glues and Protein Degraders

These novel small molecules induce cancer-causing proteins to self-destruct, offering a new mechanism to tackle tumors. Investment and clinical trials in this area are accelerating in 20254.

7. Next-Generation CAR-T Cell Therapies

CAR-T therapies continue to expand beyond blood cancers into solid tumors, with new FDA approvals and innovations like in vivo CAR-T generation making these treatments more accessible and effective for a broader range of patients (4, 8).

8. Overcoming Drug Resistance

New therapies focused on stabilizing tumor suppressor proteins and blocking cancer escape pathways are tackling one of oncology’s greatest challenges—treatment resistance—helping patients achieve longer-lasting remissions126.

Another emerging strategy involves repurposing existing drugs (below) to overcome drug resistance commonly seen in stage 4 or metastatic cancers25. These approaches include targeting the p53 tumor suppressor pathway, which is frequently impaired in cancers. Small molecules such as MDM2 inhibitors and novel agents like RIPTAC therapeutics aim to restore or modulate p53 function, inducing selective cancer cell death while minimizing toxicity to healthy cells13. Combination therapies that enhance p53 pathway modulation and target downstream processes such as apoptosis, cell cycle arrest, and immune response are leading the way in improving treatment efficacy and overcoming resistance25.


9. Repurposed Drugs for Cancer Therapy

Old meets new. Repurposing existing drugs—using 'old drugs' for new purposes—offers a cost-effective and faster route to new cancer treatments. These drugs have established safety profiles and are being actively studied for their ability to target tumor cells and the tumor microenvironment, often as part of combination therapies. This approach addresses challenges like drug resistance and toxicity while accelerating clinical application12367.

A significant breakthrough in 2025 is the growing use of repurposed drugs as alternative cancer treatments—medications originally developed for non-cancer conditions but now showing promise in oncology. Drugs like ivermectin, mebendazole, and fenbendazole, traditionally used as antiparasitic agents, are being studied for their anticancer properties. A peer-reviewed protocol published in September 2024, led by researchers such as Dr. Ilyes Baghli and Dr. Paul Marik, demonstrates that these drugs can disrupt cancer cell growth by targeting microtubules, essential for cell division [Baghli et al 2024].

A significant breakthrough in 2025 is the growing use of repurposed drugs—medications originally developed for non-cancer conditions but now showing promise in oncology. Drugs like ivermectin, mebendazole, and fenbendazole, traditionally used as antiparasitic agents, are being studied for their anticancer properties. A peer-reviewed protocol published in September 2024, led by researchers such as Dr. Ilyes Baghli and Dr. Paul Marik, demonstrates that these drugs can disrupt cancer cell growth by targeting microtubules, essential structures for cell division. When used in combination, they exhibit a synergistic effect, offering a potent, affordable treatment option [Baghli et al 2024].

Additionally, drugs like metformin, originally developed for diabetes, and anastrozole, a breast cancer treatment now repurposed for prevention, are gaining traction. Metformin disrupts cancer cell metabolism, while anastrozole reduces estrogen levels to lower breast cancer risk. These repurposed drugs are particularly valuable in low- and middle-income countries, where access to expensive therapies is limited, and their established safety profiles accelerate their integration into clinical practice.

While anecdotal reports, including over 150 case studies on fenbendazole, suggest potential benefits, controlled clinical trials are essential to confirm its efficacy and safety. Patients considering fenbendazole or similar treatments should consult integrative oncologists to develop personalized protocols that address their specific needs and monitor for possible risks such as inflammation, liver toxicity, or cancer progression. Current evidence highlights fenbendazole’s promising anticancer mechanisms observed in laboratory studies, but its poor oral bioavailability and lack of robust clinical data warrant caution and professional guidance before use123.

10. Cyclic Peptide Therapies

Cyclic peptides represent an emerging class of targeted drugs that disrupt tumor growth by binding specific receptors. Early clinical successes and pharma interest suggest they could become a major new therapy class4.

The Future is Bright

With these breakthroughs on the horizon, 2025 is set to be a landmark year in the fight against cancer. Whether it’s a vaccine that prevents relapse, a pill that targets the “untreatable,” or AI that finds cancer before symptoms appear, these therapies are rewriting the rules—and giving hope to millions worldwide.

Stay tuned. The revolution in cancer care is just getting started.

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