Top 10 Prostate Cancer Fighting Supplements 2025

The prostate is a gland that’s part of the male reproductive system. It’s about the size of a walnut, wraps around the upper part of the urethra, and is responsible for making most of the fluid in semen (Source). Prostate cancer is the most commonly diagnosed cancer in men worldwide and the fourth leading cause of cancer deaths in men.

The following is a list of plausible supplements that, in addition to diet and lifestyle measures, might help halt or slow the progression of prostate cancer:

Best Supplements for Prostate Cancer

1) Omega-3

The CAPFISH-3 RCT Study (2024) concluded that "a high omega-3, low omega-6 diet with Fish Oil for 1 year resulted in a significant reduction in Ki-67 index, a biomarker for prostate cancer progression, metastasis, and death.”

2) Curcumin

Via its documented anti-inflammatory effects, this potent extract of the spice turmeric tamps down the chronic inflammation that may give rise to prostate cancer. In addition to its preventive benefits, curcumin has been shown to stop the formation of metastases in prostate cancer patients.

3) Vitamin D3

Proceeding from the observation that prostate cancer is more prevalent and more aggressive in African American men (darker skin pigment blocks the UV rays that promote skin synthesis of vitamin D), researchers have explored the role of vitamin D as a preventive. In a small trial (2015), men about to undergo prostate surgery were given 4000 IU of vitamin D3 daily for just 60 days. Compared to men taking a placebo, their tumors were found to be smaller and less aggressive.

Buying Guide: Most vitamin D3 supplements include vitamin K2. Click here to buy vitamin D3 and K2.

4) EGCG

Epigallocatechin gallate, a catechin found in green tea, has been shown to offer protection against many cancers. Japanese men who drank more than five cups of green tea per day were found to have significantly reduced risk of prostate cancer. A 2011 study called for investigation of whether green tea polyphenols might be used for chemo-prevention of prostate cancer. A single 500 mg 70% EGCG capsule provides approximately the equivalent of the EGCG found in 5-7 cups of green tea.

5) Resveratrol

Population studies show that users of resveratrol-rich red wine have a lower incidence of prostate cancer. Resveratrol works through more than a dozen different anticancer mechanisms and selectively targets cancer cells.

6) Flax Seed Lignins (Brevail)

The enterolactones that are metabolic byproducts of dietary lignins protect against hormonally-mediated cancers. A study showed that men who had the highest serum enterolactone concentrations were 82 percent less likely to have prostate cancer compared with men who had the lowest concentration. 

7) Melatonin: 

Long associated with its sleep-inducing properties, melatonin fights breast and prostate cancer. A dose higher than is customarily used for sleep or jet lag—20 mg—appears to confer survival benefits, and may counteract harmful effects of radiation and chemotherapy without diminishing their efficacy.

8) Vitamin E and 9) Selenium: 

After several studies showed that vitamin E and selenium might protect against prostate cancer, a large trial called SELECT was recently undertaken. The results were disappointing, and researchers concluded that E and selenium were worthless for prostate cancer prevention. But they may have used the wrong forms of these nutrients—d-alpha tocopherol vitamin E and selenomethionine. When gamma tocopherol E was tested, men were found to have a 32% lower risk of prostate cancer. Methylselenocysteine was found to inhibit prostate cancer cell growth, and was synergistic with potent chemotherapy drugs.

10) Quercetin

A potent bioflavonoid found in onions, apples, black tea, and buckwheat, a number of recent studies have demonstrated that quercetin inhibits the growth of prostate cancer. 


Prostate Supplement Is Useful, but Don’t Solely Rely on It

While a supplement is not a magic bullet, its potential benefit with virtually no downside makes it a compelling option for most people. That said, it's important to remember that dietary supplementation isn't a replacement for a healthy lifestyle. Proper nutrition, regular exercise, quality sleep and stress management remain the foundations of good health. Supplements can be seen as an additional support to these core practices.


Sources and References: 

Best Supplements for Prostate Cancer

This debunked prostate cancer treatment may give you Alzheimer’s?

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