Cancer Advisor

Abstract Background : Stage 4 prostate cancer remains largely incurable, and new strategies are urgently needed. Preclinical evidence suggests antiparasitic agents such as ivermectin and mebendazole, when combined with anti-inflammatory supplements and lifestyle changes, may offer survival benefits. Objective : To simulate the long-term efficacy and safety of a combined therapeutic protocol including high-dose ivermectin, mebendazole, nutritional supplements, and structured lifestyle changes in patients with stage 4 prostate cancer. Methods : A double-blind, randomized, placebo-controlled simulation trial was designed with 10,000 patients per arm over a 10-year follow-up. The intervention arm received high-dose ivermectin (1 mg/kg, 5x/week), mebendazole (500 mg BID), supplements (vitamin D, curcumin, omega-3, EGCG, berberine), and a structured diet/lifestyle protocol. The control arm received standard of care plus placebo. Survival outcomes and adverse event rates were simulated usi...

Abstract Background:  Stage IV pancreatic ductal adenocarcinoma (PDAC) lacking actionable mutations has limited treatment options, with median overall survival (mOS) of 9–11 months using standard chemotherapy. Repurposed drugs (ivermectin, mebendazole) and hyperthermia show preclinical promise. This in silico randomized controlled trial (RCT) evaluates an integrative protocol combining ivermectin, mebendazole, hyperthermia, supplements, and lifestyle interventions versus standard-of-care (SOC) NALIRIFOX chemotherapy in non-BRCA-mutated stage IV PDAC. Methods:  A simulated two-arm RCT enrolled 200 patients with non-BRCA-mutated stage IV PDAC, randomized 1:1 to an experimental arm (ivermectin 1 mg/kg/day 3 days/week, mebendazole 500 mg twice daily, localized hyperthermia 42–43°C 3 sessions/week, supplements [vitamin C, vitamin D, curcumin, berberine], ketogenic diet, intermittent fasting, pancreatic enzymes) or control arm (NALIRIFOX). Primary endpoint was 12-month overall surv...

Contents Introduction Methodology Best Alternative Cancer Treatments Ivermectin Mebendazole/Fenbendazole/Albendazole (Benzimidazole) Glucose Management, Keto Diet and GLP-1 Receptor Agonists Stress Reduction, Sleep, and Sunshine Vitamin D3 Exercise Curcumin (Nanocurcumin) Green Tea (EGCG) Omega-3 Fatty Acids Berberine Propranolol Melatonin Metformin Atorvastatin or Simvastatin Sildenafil, Tadalafil, and Vardenafil Disulfiram Ashwagandha Itraconazole Aspirin and Celecoxib (Celebrex) Vitamin C DMSO BCG Treatment Methylene Blue Hyperthermia HBOT (Hyper Baric Oxygen Therapy) Gerson Therapy Conclusion Introduction Facing a cancer diagnosis can feel like navigating an endless maze with no clear direction. The overwhelming emotions and confusion that accompany such news are shared by many. While conventional cancer treatments like chemotherapy and radiation therapy have a role to play, there’s a growing interest in alternative therapies that can complement or even replace traditional methods....