Cancer Advisor

Abstract Cancer continues to pose a significant global health burden, particularly with the rise of aggressive and treatment-resistant malignancies such as triple-negative breast cancer, pancreatic adenocarcinoma, and glioblastoma. In response to the limitations of current therapies, there is growing interest in the repurposing of antiparasitic agents—specifically fenbendazole—for oncological applications. This review synthesizes recent preclinical and emerging clinical evidence on the anticancer mechanisms and therapeutic potential of this drug. Fenbendazole, a benzimidazole compound, demonstrates anticancer activity through microtubule destabilization, cell cycle arrest, and inhibition of glucose metabolism, though its clinical application is challenged by poor solubility and bioavailability. Despite promising laboratory and anecdotal clinical results, robust randomized controlled trials are lacking, and regulatory approval for cancer indications remains limited. The review highlight...