Androgen Deprivation Therapy (ADT) in 2026: Benefits, Risks and New Research in Prostate Cancer
Prostate cancer is one of the most hormone-sensitive cancers in medicine. For decades, doctors have used androgen deprivation therapy (ADT) — also called hormone therapy — to slow or shrink prostate tumors by reducing testosterone levels. For many men, ADT can be life-extending and highly effective. But there’s another side to the story. Modern research shows that long-term testosterone suppression can affect nearly every system in the body — including the heart, brain, muscles, bones, metabolism and emotional health. Today, ADT is increasingly viewed as a double-edged sword: powerful against prostate cancer, but potentially costly to long-term health and quality of life. Here’s what the latest evidence says about ADT in 2026. What Is Androgen Deprivation Therapy (ADT)? Androgen deprivation therapy lowers male hormones — primarily testosterone and dihydrotestosterone (DHT) — that help prostate cancer cells grow. Because many prostate tumors depend on androgen signaling, reducing testos...