Ivermectin in Ovarian Cancer: Ivermectin synergy with a statin - 2023 Paper by UK and Iraqi researchers

By Editorial Team

Ivermectin + Statin: New Repurposed Drug combination for Cancer

2023 Jawad et al - Ivermectin augments the anti-cancer activity of pitavastatin in Ovarian Cancer Cells.



HIGHLIGHTS: Researchers previously showed pitavastatin (a cholesterol lowering statin drug) can kill ovarian cancer cells at high doses They wanted to identify a drug synergistic with pitavastatin to lower the dose needed for pitavastatin to be effective in Ovarian cancer They tested IVERMECTIN + PITAVASTATIN in 6 Ovarian Cancer cell lines. They tested the two drugs, separately and together, on six different lab-grown ovarian cancer cell lines (including COV-318 cells). They measured: How much the drugs (Ivermectin, Pitavastatin) slowed or stopped cancer cell growth. Whether the combination caused more cancer cells to die (apoptosis). RESULTS: Ivermectin used at lower dose had only a mild effect on Ovarian Cancer cells. Ivermectin + Pitavastatin had a strong synergistic effect. DISCUSSION: Previous work from Ricardo et al. has shown a synergistic interaction between pitavastatin, paclitaxel, and ivermectin in Ovarian Cancer These authors found that these drugs synergistically decreased the viability of paclitaxel-resistant Ovarian Cancer cells. “We are particularly interested in whether statins can be used as an alternative to chemotherapy, possibly in patients who have become resistant to chemotherapy, so we explored the combination of pitavastatin and ivermectin in the absence of paclitaxel.” “In this study, we report synergy between pitavastatin and ivermectin, and this synergy may contribute to the synergy observed in the triple-drug combination evaluated by Ricardo” A synergistic interaction was observed in Fuov-1, Cov-362 and Cov-318 Ovarian Cancer cells. In the latter two cells, synergy was observed at multiple concentrations of Ivermectin CONCLUSION: Repurposed drugs are the FUTURE of Cancer Care.


Sources & References:

  1. Jawad et al. Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells. Diseases 2023.
  2. Makis W. Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells. X.com 2026.
  3. 27 Best Alternative Cancer Treatments 2026: Proven Interventions. Cancer Advisor 2026.

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