Fenbendazole in Melanoma - synergy with VERZENIO - 2025 South Korean paper

By Editorial Team

2025 Se-Hoon Kim et al - Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with Fenbendazole. (1)



Highlights 
  • Abemaciclib (VERZENIO), a CDK4/6 inhibitor, is well-established for treating hormone receptor-positive and HER2-negative (HR+/HER2−) human breast cancer.
  • Five canine melanoma (skin cancer) cell lines were used to evaluate the antitumor effects of abemaciclib. 
  • Synergistic effects with fenbendazole were evaluated.

RESULTS:

  • Abemaciclib induced G1 cell cycle arrest, autophagy (but not apoptosis)
  • Co-treatment with fenbendazole enhanced cytotoxicity and showed synergistic effects within specific dose ranges.
  • Mouse tumors were smaller.
  • mouse body weight remained same (treatment was well tolerated).
  • Synergistic interaction with Fenbendazole suggests a potential combinatorial therapeutic approach for canine melanoma.
CONCLUSION: This study showed that a new generation Targeted therapy for breast cancer (abemaciclib) or VERZENIO, has synergy with Fenbendazole in killing cancer cells and stopping tumor growth (melanoma in this case). COMMENTS: Fenbendazole research in cancer continues to produce shocking results.


References:

  1. Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole
  2. Makis W. Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole: Review by Dr William Makis. X.com 2026.

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