Prostate Cancer Research Highlights (2025 - 2026)
Prostate cancer is the second most commonly diagnosed cancer in men globally and a leading cause of cancer-related mortality. Despite widespread prostate-specific antigen (PSA) screening and advances in systemic therapies, clinical outcomes vary widely, particularly in metastatic and castration-resistant disease. Traditional research paradigms have emphasized pharmacologic intervention after disease onset; however, recent evidence increasingly highlights the importance of modifiable risk factors, structural inequities, and metabolic health.
At the same time, patient-driven experimentation with repurposed drugs—often outside conventional clinical trials—has gained visibility, raising important scientific and ethical questions. This resource page compiles an integrated update across prevention, treatment, and emerging off-label approaches.
Risk Factors and Prevention
- Grains May Lower Advanced Prostate Cancer Risk (Y Wang)
- Prostate Cancer and Neighborhood Stress
- "Forever Chemicals" Not Linked with Prostate Cancer in Older Men
- Cruciferous Vegetable Intake and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis (2023)
- Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis (BMJ 2021)
- Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis (2021)
- The CAPFISH-3 RCT Study (2024) concluded that "a high omega-3, low omega-6 diet with Fish Oil for 1 year resulted in a significant reduction in Ki-67 index, a biomarker for prostate cancer progression, metastasis, and death.”
Treatment
- 2 Potential New Drug Pathways to a Prostate Cancer Target
- Proton Beam Therapy for Prostate Cancer Still Needs Studying
- Prostatectomy for Black Men Who Also Have Obesity (A Vidal)
- Medicaid Alone Doesn't Improve Prostate Cancer Care (C Filson)
- New Immunotherapy for PC Bone Mets (L Cook)
- Heart Medicines May Spur Future Prostate Treatments (I Schlaepfer)
- Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy (Cancer Research 2024)
2025 ASCO Annual Meeting Updates
- Final overall survival (OS) with talazoparib (TALA) + enzalutamide (ENZA) as first-line treatment in unselected patients with metastatic castration-resistant prostate cancer (mCRPC) in the phase 3 TALAPRO-2 trial.
- FDA Approves Darolutamide for Metastatic Castration-Sensitive Prostate Cancer
- ASCO Updates Guidelines for Metastatic Castration-Resistant Prostate Cancer
Clinical Trials of Metastatic Prostate Cancer
There are more than 3,000 clinical trials of ClinicalTrials.gov on metastatic prostate cancer.
Case Reports (Repurposed Drugs)
- Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients -(Case Reports in Oncology 2025)
- Fenbendazole and Ivermectin for Prostate Cancer? A Case Series of 55 Patients (January 2026 Edition)
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